Proteolytic stability in gastrointestinal tract and blood plasma is the major obstacle for oral peptide drug development. Inhibitor cystine knots (ICKs) are linear cystine knot peptides which have multifunctional properties and could become promising drug scaffolds. ProTx-I, ProTx-II, GTx1-15, and GsMTx-4 were spider-derived ICKs and incubated with pepsin, trypsin, chymotrypsin, and elastase in...

conclusions wheat germ extract seems to be an effective treatment for dysmenorrhea and its systemic symptoms, probably because of its anti-inflammatory effects. results pain severity decreased only in the wheat germ extract group (p < 0.001) and there was no statistically significant change in the placebo group. in the wheat germ extract group, the pain severity decreased from 4.701 at baseline...

background: owing to the growing importance of medicines in treatment of diseases, as well as their role as alternatives for expensive and often unsafe procedures; economic examination of factors associated with their demand is necessary. hence, this study aimed at exploring factors affecting the demand of specialty medicines.   methods: in this descriptive-analytic study, data was collected fr...

background: hot flashes are the most common symptoms experienced by women around the time of menopause. many women are interested in herbal medicines because of fear of side effects of hormone therapy. objective: the aim of this systematic review was to assess the effectiveness of iranian herbal medicines in alleviating hot flashes. materials and methods: medline (1966 to january 2015), scopus ...

Microparticles are small fragments (0.1-1.0 μm) of cellular membrane which are shed by cells under conditions of stress. As levels of circulating microparticles are elevated in disease, there has been significant interest in their assessment and quantification under pathological conditions. Here we describe a protocol for the isolation of microparticles from plasma samples and their characteriz...

background: plasminogen is one of the compounds derived from human plasma. activation of plasminogen produces plasmin. plasmin is able to lyse fibrinogen, fibrin, and some other human plasma proteins. the aim of the present work was to study the separation of human plasminogen by affinity chromatography using gel lysine sepharose. materials and methods: normal human plasma was used as the start...

one of the most important duties of government in public health sector is to provide secured sources for medicines supply. there are some regulations for domestic pharmaceutical industry. in addition, there is a discipline for importing medicine to be ensured about their claimed characteristics. in medicines registration process, moh (fdo in iran) assess ‘safety’, ‘quality’ and ‘efficacy’ of me...

BACKGROUND Medicine-related burden is an increasingly recognized concept, stemming from the rising tide of polypharmacy, which may impact on patient behaviors, including nonadherence. No instruments currently exist which specifically measure medicine-related burden. The Living with Medicines Questionnaire (LMQ) was developed for this purpose. OBJECTIVE This study validated the LMQ in a sample...