1. In twenty-two patients representing different stages of benign essential hypertension, hyperosmotic saline was administered intravenously. Determinations of intra-arterial pressure, renal plasma flow, glomerular filtration rate and plasma renin concentration were carried out before and, in the majority, also during and after saline infusion. Changes in cardiac output were followed in ten pat...

product contained, on the average, 67 units of antihemophilic activity per mg of protein, and was 3360-fold purified compared with the filtered plasma. The molecular weight of antihemophilic factor appeared to be at least two million. Preparations separated by gel filtration were contaminated with appreciable amounts of plasma thromboplastin antecedent (PTA), and traces of Christmas factor and ...

The determination of the ;cortisol-binding capacity' by gel filtration of a small plasma sample at low temperature after the addition of cortisol results in an arbitrary measurement dependent upon experimental conditions. It is unsatisfactory also because it misleads as to conditions at 37 degrees C. Steady-state gel filtration of cortisol in plasma can be done at 37 degrees C, at which tempera...

Although considerable progress has been achieved in the study of the coagulation of plasma by staphylocoagulase, the precise identity of the coagulase-reacting factor (CRF) has remained in doubt. The claims linking CRF with various factors involved in the dotting of blood have been recently summarized elsewhere (1). Questions pertaining to the possible relation of CRF to prothrombin have remain...

Podocytes are specialized epithelial cells in the kidney glomerulus that play important structural and functional roles in maintaining the filtration barrier. Nephrotic syndrome results from a breakdown of the kidney filtration barrier and is associated with proteinuria, hyperlipidemia, and edema. Additionally, podocytes undergo changes in morphology and internalize plasma proteins in response ...

Shannon and Smith (1) found that in normal man, the rate of excretion of inulin was directly proportional to its concentration in plasma when the latter varied from 50 to 400 mg. per cent. Later Miller, Alving, and Rubin (2). extended these observations to plasma concentrations of inulin between 3 and 96 mg. per cent and reached similar conclusions. Both groups considered that this constituted ...

product contained, on the average, 67 units of antihemophilic activity per mg of protein, and was 3360-fold purified compared with the filtered plasma. The molecular weight of antihemophilic factor appeared to be at least two million. Preparations separated by gel filtration were contaminated with appreciable amounts of plasma thromboplastin antecedent (PTA), and traces of Christmas factor and ...

The whole blood viscosity (WBV) is one of the major independent indicators for the risk of cardiovascular disease, stroke, and peripheral arterial diseases. Furthermore, oxidized LDL molecules are known to cause atherosclerotic plaques in arteries, and it is one of the key components that increase WBV. The present study attempted to reduce WBV by coagulating plasma proteins and lipid molecules ...

Chronic electric activation of the carotid baroreflex produces sustained reductions in sympathetic activity and arterial pressure and is currently being evaluated as hypertension therapy for patients with resistant hypertension. However, the chronic changes in renal function associated with natural suppression of sympathetic activity are largely unknown. In normotensive dogs, we investigated th...

Chantler, C., and Barratt. T. M. (1972). Archives of Disease in Childhood, 47, 613. Estimation of glomerular filtration rate from plasma clearance of 51-chromium edetic acid. The glomerular filtration rate was estimated by a single compartment analysis of the rate of fall of plasma concentration of 51-chromium edetic acid after a single intravenous injection. This slope clearance consistently o...