Background: Plasminogen activator inhibitor-1 (PAI-1) is a glycoprotein with inhibitory effects on the formation of plasmin from plasminogen by plasminogen activator. Thus, it prevents clot lysis in vessel walls. Several evidences prove the relationship between coronary artery disease and response to fibrinolytic therapy in patients with myocardial infarction with PAI-1 level. Opium addiction i...

Homozygous plasminogen-deficient (Plg-/-) mice had a significantly reduced thrombolytic capacity toward intravenously injected 125I-fibrin labeled plasma clots prepared from Plg-/- murine plasma (9% +/- 3% lysis after 8 hours; (mean +/- SEM, n = 6), as compared with 82% +/- 8% in wild-type mice; P < .0001). Bolus injection of 1 mg purified murine plasminogen in 10- to 17-week-old Plg-/- mice in...

A patient who suffered a recurring thrombosis over the last 15 yr has been investigated. The only abnormality found in this patient was a significantly depressed level of plasminogen activity in plasma. In spite of the depressed plasminogen activity, the patient was found to have a normal level of plasminogen antigen concentration. It was calculated that the activity per milligram of plasminoge...

Plasminogen in full term newborn infants has been measured by functional and immunological assays. Plasminogen functional activity and antigen concentration in newborn infants were about 44% and 48% of adult values respectively. Physiological activation kinetics of plasminogen in undiluted plasma at pH 7.4 and 37 degrees C using various concentrations of streptokinase and urokinase showed no si...

Activation of plasminogen through surface-mediated reactions is well recognized. In the presence of kaolin, purified Hageman factor (Factor XII) changed plasminogen to plasmin, as assayed upon a synthetic amide substrate and by fibrinolysis. Kinetic studies suggested an enzymatic action of Hageman factor upon its substrate, plasminogen. Hageman factor fragments, at a protein concentration equiv...

Several pathogenic bacterial species intervene with the mammalian proteolytic plasminogen-plasmin system. Recent developments have been made in understanding the structure and the virulence-associated functions of bacterial plasminogen receptors and activators, in particular by using plasminogen-deficient or transgenic gain-of-function mice. Bacteria can affect the regulation of the plasminogen...

Introduction: In this study, coagulation and fibrinolysis parameters their association with disease severity were investigated in coronavirus (COVID-19) patients. Materials Methods: COVID-19 patients (n = 446) admitted to our institute between 21 February 2021 17 March 2022, recruited. Clinical data staging collected from all Blood samples analyzed for several of coagulation, including alpha-2-...

Background: To analyze the correlations between plasma coagulation factor VII (FVII), plasminogen activator inhibitor-1 (PAI-1), uric acid, and insulin resistance (IR) diabetic macroangiopathy (DMAP) in elderly patients with type 2 diabetes mellitus (T2DM).

The effect of Escherichia coli strains isolated from blood and cerebrospinal fluid of septic infants on plasminogen activation was studied. These strains typically carry a filamentous surface protein, S fimbria, that has formerly been shown to bind to endothelial cells and interact with plasminogen. The. bacteria effectively promoted plasminogen activation by tissue plasminogen activator (t-PA)...

BACKGROUND Previous experimental work using in situ zymography has shown very early increased plasminogen activation in ischemic regions after 3 h of ischemia with and without reperfusion. The objective of the present study was to evaluate the time course and extent of plasminogen activation in long-term permanent focal cerebral ischemia. MATERIAL AND METHODS The middle cerebral artery in mal...