نتایج جستجو برای: plasmodium falciparum
تعداد نتایج: 27378 فیلتر نتایج به سال:
Wild-living chimpanzees and gorillas harbor a multitude of Plasmodium species, including six of the subgenus Laverania, one of which served as the progenitor of Plasmodium falciparum. Despite the magnitude of this reservoir, it is unknown whether apes represent a source of human infections. Here, we used Plasmodium species-specific PCR, single-genome amplification, and 454 sequencing to screen ...
OBJECTIVE To determine the frequency of thrombocytopenia in malarial parasite (MP) positive patients. STUDY DESIGN A cross-sectional study. PLACE AND DURATION OF STUDY Medical Unit-III, Ward-7, JPMC, Karachi, from June to October 2006. METHODOLOGY One hundred twenty four MP positive cases were included in the study. Infections with both Plasmodium falciparum and Plasmodium vivax species w...
background: our study aimed at substantiating the recent claim of myo-cardial complications in severe malaria by experimentally inducing severe plasmodium falciparum infection in a humanized mouse model employed as human surrogate. methods: twenty five humanized mice were inoculated with standard in vitro cultured p. falciparum and blood extracts collected from the inner cardiac muscles of infe...
Plasmodium falciparum malaria poses an increasing risk to travellers to West Africa. The development of chloroquine resistant in West Africa has further compounded the risk. Two cases of falciparum malaria from Sierra Leone are presented. One represents the classic missed case and the other a probable case of chloroquine resistant (RI vide infra) falciparum malaria. These cases highlight the da...
Plasmodium falciparum (P. falciparum) is the main parasite known to cause malaria in humans. The antimalarial drug atovaquone inhibit Qo-site of cytochrome bc1 complex P. falciparum, which ultimately blocks ATP synthesis, leading cell death. Through years, mutations complex, causing resistance atovaquone, have emerged. present investigation applies molecular dynamics (MD) simulations study how ...
Artemisinin resistance in Plasmodium falciparum threatens the remarkable efficacy of artemisinin-based combination therapies worldwide. Thus, greater insight into the resistance mechanism using monitoring tools is essential. The ring-stage survival assay is used for phenotyping artemisinin-resistance or decreased artemisinin sensitivity. Here, we review the progress of this measurement assay an...
Clinical data indicate that oxidative stress and activities may play important roles in Plasmodium falciparum. The aim of this study was to assess the erythrocyte antioxidants and evaluate enzyme activities as marker for Plasmodium falciparum malaria patients. The diagnosis of malaria was confirmed by thick and thin film with Giemsa staining of malaria parasite. Ninety consenting individuals, s...
The mosquito Anopheles gambiae uses its innate immune system to control bacterial and Plasmodium infection of its midgut tissue. The activation of potent IMD pathway-mediated anti-Plasmodium falciparum defenses is dependent on the presence of the midgut microbiota, which activate this defense system upon parasite infection through a peptidoglycan recognition protein, PGRPLC. We employed transcr...
Plasmodium falciparum proteasome (Pf20S) inhibitors are active against at multiple stages—erythrocytic, gametocyte, liver, and gamete activation stages—indicating that selective Pf20S possess the potential to be therapeutic, prophylactic, transmission-blocking antimalarials. Starting from a reported compound, we developed noncovalent, macrocyclic peptide inhibitor of malarial with high species ...
Background:Malaria infection is still one of the most important public health concerns globally. The aim of this study was to evaluate retrospective epidemiological study of malaria in Khash City, Sistan and Baluchestan Province of Iran from 1999 to 2016. Methods:This was a retrospective study, which collected official data of 26-year trend of malaria in ...
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