The serine/threonine kinase Polo-like kinase 1 (Plk1) is overexpressed in many types of human cancers, and has been implicated as an adverse prognostic marker for cancer patients. Plk1 localizes to its intracellular anchoring sites via its polo-box domain (PBD). Here we show that Plk1 can be inhibited by small molecules which interfere with its intracellular localization by inhibiting the funct...

With programming-by-demonstration (PBD), a user shows examples of a behavior that the computer is meant to perform instead of writing out textual instructions. Many PBD systems use machine-learning techniques to convert the user’s examples into executable programs automatically. However, in order to use PBD as a general-purpose programming tool, the user must be able to demonstrate more than ju...

The pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) are a family of sequence-selective DNA minor-groove binding agents that form a covalent aminal bond between their C11-position and the C2-NH2 groups of guanine bases. The first example of a PBD monomer, the natural product anthramycin, was discovered in the 1960s, and the best known PBD dimer, SJG-136 (also known as SG2000, NSC 694501 or BN2629), wa...

BACKGROUND Polo-like kinase-1 (Plk1) plays a crucial role in cell proliferation and the inhibition of Plk1 has been considered as a potential target for specific inhibitory drugs in anti-cancer therapy. Several research groups have identified peptide-based inhibitors that target the polo-box domain (PBD) of Plk1 and bind to the protein with high affinity in in vitro assays. However, inadequate ...

BACKGROUND Recent research evidence suggests that executive function (EF) is impaired in both pediatric bipolar disorder (PBD) and attention deficit-hyperactivity disorder (ADHD), although the underlying cognitive mechanisms are still unclear. In this study we examined EF, including cognitive and emotional control, in three pediatric groups with overlapping symptoms. METHODS Sixteen children ...

In order to empower user data protection and rights, the European General Data Protection Regulation (GDPR) has been enforced. On positive side, is obtaining advantages from GDPR. However, organisations are facing many difficulties in interpreting GDPR, properly applying it, and, meanwhile, due their lack of compliance, receiving huge fines authorities. An important challenge compliance with Pr...

BACKGROUND Hematoma of the auricle which is a collection of blood beneath the perichondrial layer of the pinna usually poses a challenge to the otolaryngologist due to its high rate of recurrence after treatment and lack of appropriate material for use as stitch dressing especially, in the developing world. This is a Pilot study in which corrugated rubber drain was used as a stitch dressing aft...

The objective of this study was to investigate the effects of different preoperative biliary drainage (PBD) methods on complications in jaundiced patients following pancreaticoduodenectomy. We retrospectively analyzed 270 extrahepatic bile duct cancer patients who underwent pancreaticoduodenectomy. A total of 170 patients without PBD treatment were defined as the non-PBD group. According to dif...