The inflammatory response involves sequential adhesive interactions between cell adhesion molecules of leukocytes and the endothelium. Unlike the several adhesive steps that precede it, transendothelial migration (diapedesis), the step in which leukocytes migrate between apposed endothelial cells, appears to involve primarily one adhesion molecule, platelet-endothelial cell adhesion molecule (P...

background: recent evidences have supported migraine headache and neurally mediated syncope as the especial types of endotheliopathies. to determine endothelial function in patients with migraine headache or those with neurally mediated syncope,the present study was conducted. materials and methods: this cross-sectional study was performed on 93 consecutive patients aged 5-20 years in four grou...

A great deal of progress has been made recently in understanding the molecules and mechanisms that regulate transendothelial migration of leukocytes, or diapedesis, a critical step in the inflammatory response. This review focuses mainly on the active role of the endothelial cell in this process as it occurs at endothelial cell borders. It discusses some of the many molecules that have been rep...

Curcumin has protective effects against toxic agents and shows preventive properties for various diseases. Particulate material with an aerodynamic diameter of ≤10 μm (PM10) and titanium dioxide nanoparticles (TiO2-NPs) induce endothelial dysfunction and activation. We explored whether curcumin is able to attenuate different events related to endothelial activation. This includes adhesion, expr...

RATIONALE Protein S-palmitoylation is the posttranslational attachment of a saturated 16-carbon palmitic acid to a cysteine side chain via a thioester bond. Palmitoylation can affect protein localization, trafficking, stability, and function. The extent and roles of palmitoylation in endothelial cell (EC) biology is not well-understood, partly because of technological limits on palmitoylprotein...

background: this study attempted to determine the effects of long-term use of vitamin c on vascular endothelial function. materials and methods: during a pilot clinical trial study conducted at imam hussein hospital (isfahan) in 2014-2015, a total of 40 diabetic patients were selected and then assigned randomly into two 20-subject groups receiving vitamin c and placebo tablets. the patients wer...