conclusions helicobacter pylori infection has a significant effect on platelet count in patients with citp and h. pylori eradication therapy should be considered as an important factor in platelet count recovery in citp patients. results from a total of 23 patients with citp, 43% (10) of the cases were h. pylori positive and after eradication therapy, eight patients (80%) were successfully trea...

Two heparin-neutralizing proteins secreted by thrombin-stimulated platelets were purified to homogeneity by means of heparin-agarose affinity chromatography. These proteins, termed porcine platelet basic protein (PBP) and porcine platelet factor 4 (PF4), were eluted from a heparin-agarose column at 0.6-0.9 M NaCl and at 1-1.4 M NaCl, respectively. The molecular weight of porcine platelet basic ...

IN TESTS OF PLATELET FUNCTION IN NORMAL SUBJECTS, THE FOLLOWING RELATIONSHIPS WERE FOUND: the greater the platelet adhesiveness the less the ability to disaggregate after challenge with adenosine diphosphate (ADP), and the greater the disaggregation after ADP, the longer the clotting time in the test for platelet factor 3 availability. Such correlations were disturbed in uraemic patients.

Platelet function has been studied in 16 patients with uncomplicated infectious mononucleosis. Some abnormality of platelet aggregation and/or release of platelet factor III or platelet factor IV was found in all patients. Six patients with platelet defects were retested after three to four months and were found to have normal platelet function and appreciably higher platelet counts. Abnormal p...

Platelet-derived growth factor was purified from fresh platelets by a large-scale procedure not involving the use of SDS (sodium dodecyl sulphate). The product, 0.5 mg of platelet-derived growth factor, obtained from about 3 x 1013 platelets migrated as a single component in analytical gel electrophoresis in the presence of SDS and showed no inhomogeneity on sedimentation-equilibrium analysis i...

Two families were studied because of a hemorrhagic tendency. The presumptive diagnosis of von Willebrand’s disease was suggested by low factor VIII levels (7.5%33%), prolonged template Ivy bleeding time (9.5-17 mm), low platelet adhesiveness (0%-8%), normal platelet factor 3, and normal clot retraction. Further studies, however, showed abnormal platelet aggregation with ADP, epinephrine, and co...

preparations of platelet concentrates (pcs) that are stored under blood bank conditions and used for transfusion purposes, appear to be enriched in platelet derived-microparticles (pmps) with high coagulant activity that may change platelet efficacy and safety issues. high shear stress could cause shedding of pmps from the platelet plasma membrane, platelet aggregation, and activation of the co...

The murine/human chimeric monoclonal antibody fragment (c7E3 Fab) blocks GPIIb/IIIa and alpha v beta 3 receptors, inhibits platelet aggregation, and decreases the frequency of ischemic events after coronary artery angioplasty in patients at high risk of suffering such events. Although inhibition of platelet aggregation is likely to be the major mechanism of c7E3 Fab's effects, since activated p...

Background Neutrophil activation and the generation of neutrophils extracellular traps (NETs) contribute to vascular damage thrombosis in antiphospholipid syndrome (aPS). We reported that Low molecular weight heparin (LMWH) prevent neutrophil induced by P-selectin expressed activated platelets [1, 2] jeopardize healthy subjects ability generate NETs mobilize granule contents [3]. Objectives To ...