The stress-responding protein, GADD45α, plays important roles in cell cycle checkpoint, DNA repair and apoptosis. In our recent study, we demonstrate that GADD45α undergoes a dynamic ubiquitination and degradation in vivo, which process can be blocked by the cytotoxic reagent, arsenite, resulting in GADD45α accumulation to activate JNKs cell death pathway, thereby revealing a novel mechanism fo...

Background and Aim: Diagnosing the status of the posterior ligament complex (PLC) plays an essential role in the management of patients with thoracolumbar fractures. In this study, due to the inefficiency of existing imaging modalities in the accurate detection of PLC damage, we investigated the relevance of some imaging parameters to specific guidelines for rapid PLC injury detection. Methods...

Yes. RNA-seq can be used to quantify transcript levels from a sample. In order to perform useful statistics, one sample is insufficient. Replicates must be used to appropriately power such statistics. The RNA-seq method is an impressive advancement with many applications for studying RNA biology but it does not eliminate biological variability. If the input samples are heavily degraded or have ...

Acidovorax sp. strain MR-S7 was isolated from activated sludge in a treatment system for wastewater containing β-lactam antibiotic pollutants. Strain MR-S7 demonstrates multidrug resistance for various types of β-lactam antibiotics at high levels of MIC. The draft genome sequence clarified that strain MR-S7 harbors unique β-lactamase genes.

bluetongue is an infectious disease that primarily affects sheep. but due to serious socioeconomic consequence of it outbreaks on the international trade it has been included in the oie notifiable diseases (list a). during 2007-8, total number of 130 blood samples gathered from suspected sheep to bluetongue disease in seropositive region including khuzestan, kurdistan, fars, ilam and qum provin...

We have resolved B220+ IgM- B-lineage cells in mouse bone marrow into four fractions based on differential cell surface expression of determinants recognized by S7 (leukosialin, CD43), BP-1, and 30F1 (heat stable antigen). Functional differences among these fractions can be correlated with Ig gene rearrangement status. The largest fraction, lacking S7, consists of pre-B cells whereas the others...

Two recently published but independently derived structures, namely the X-ray crystallographic structure of ribosomal protein S7 and the "binding pocket" for this protein in a three-dimensional model of the 16S rRNA, have been correlated with one another. The known rRNA-protein interactions for S7 include a minimum binding site, a number of footprint sites, and two RNA-protein crosslink sites o...

background and objectives: phosphlipases are a group of enzymes that breakdown phosphatidylcholine (phospholipids) molecules producing second products. these produced products have a divers role in the cell like signal transduction and digestion in humans. in this research the effect of phosphatidylcholine on the expression of plc genes of a. fumigatus was studied. the plc genes of this fungus ...

International Civil Aviation Organization (ICAO) regulated Visual Aids for Navigation stated on Annex 14 Chapter 5 consist of mandatory item which provides important guidance's piloting the airplane. Presently, system visual aids navigation has been working with Constant Current Regulator (CCR) in its development there are various type at CCR used airport. One is still widely airport today NBF ...

In the paper we investigate Birkhoff’s conditions (Bi) and (Bi∗). We prove that a discrete lattice L satisfies the condition (Bi) (the condition (Bi∗)) if and only if L is a 4-cell lattice not containing a cover-preserving sublattice isomorphic to the lattice S∗ 7 (the lattice S7). As a corollary we obtain a well known result of J. Jakub́ık from [6]. Furthermore, lattices S7 and S ∗ 7 are consid...