Abstract We establish a central-limit-theorem (CLT) version of the periodic Little’s law (PLL), which complements the sample-path and stationary versions of the PLL which we recently established in order to explain the remarkable accuracy in comparisons of data-generated model simulations to direct estimates from the data for the aggregate occupancy level in a hospital emergency department. Our...

The present paper describes a systematic straightforward design of a - fractional-N PhaseLocked Loop based on HDL behavioral modeling. The proposed design consists in describing the mixed mode behavior of this - fractional-N PLL architecture starting from the specifications of each building block. The HDL models of critical PLL blocks have been described in VHDL-AMS to predict the different...

Eosinophilic esophagitis is characterized by increased infiltration and degranulation of eosinophils in the esophagus. Whether eosinophil-derived cationic proteins regulate esophageal sensory nerve function is still unknown. Using synthetic cationic protein to investigate such effect, we performed extracellular recordings from vagal nodose or jugular neurons in ex vivo esophageal-vagal preparat...

PURPOSE Primary lens luxation (PLL) in dogs is an inherited disease in which the lens is displaced from its normal position. A truncating mutation in the ADAMTS17 orthologue on CFA03 is reported to cause PLL in several breeds, mostly terriers. However, the complex inheritance pattern of PLL in miniature bull terriers (MBTs) suggests that other loci may have a modifying effect on the ADAMTS17 mu...

Endosomal entrapment is one of the main barriers that must be overcome for efficient gene expression along with cell internalization, DNA release, and nuclear import. Introducing pH-sensitive ionizable groups into the polycationic polymers to increase gene transfer efficiency has proven to be a useful method; however, a comparative study of introducing equal numbers of ionizable groups in both ...

A low power, adaptive bandwidth tracking Phase Locked Loop (PLL) is presented in this paper. Designed PLL operates over a wide frequency range of 250MHz to 1GHz with a fixed multiplication factor of 8. PLL is optimized for 0.2% UI of r.m.s. jitter over the whole frequency range with bandwidth tracking to keep the power consumption minimum. In addition, a multiplier block is used to increase the...

RESULTSdPatients with T2DM and PLL exhibited symmetrical loss of subcutaneous fat in forearms, or forearms plus calves, and acanthosis nigricans. Maximally stimulated glucose disposal rates were markedly reduced by 56% in the T2DM with PLL group compared with the control T2DM patients, whether normalized by body weight or surface area. Most PLL patients exhibited little or no insulin-mediated g...

New methods, for the design of different block diagrams of PLL, using the asymptotic analysis of high-frequency periodic oscillations, are suggested. The PLL description on three levels is made: 1) on the level of electronic realizations; 2) on the level of phase and frequency relations between inputs and outputs in block diagrams; 3) on the level of differential and integro-differential equati...

In cryopreservation of mammalian germ cells, unfertilized oocytes are one of the most available stages because these cryopreserved oocytes can be used for assisted reproductive technologies, including in vitro fertilization (IVF) and intracytoplasmic sperm injection. However, it has been generally reported that the fertility and developmental ability of the oocytes are reduced by cryopreservati...

Effective gene therapy for diseases of the circulation requires vectors capable of systemic delivery. The molecular weight of poly(L-lysine) (pLL) has a significant effect on the circulation of pLL/DNA complexes in mice, with pLL(211)/DNA complexes displaying up to 20 times greater levels in the blood after 30 minutes compared with pLL(20)/DNA. It is shown that pLL(20)/DNA complexes fix mouse c...