A previously developed poly-L-lactide scaffold releasing granulocyte colony-stimulating factor (PLLA/GCSF) was tested in a rabbit chronic model of myocardial infarction (MI) as a ventricular patch. Control groups were constituted by healthy, chronic MI and nonfunctionalized PLLA scaffold. PLLA-based electrospun scaffold efficiently integrated into a chronic infarcted myocardium. Functionalizati...

The Polyvinylpyrrolidone (PVP) / Poly (L-lactic acid) (PLLA) ultrafine blend fibers have been prepared for the first time by electrospinning. Trichloromethane was found to be the co-solvent for electrospinning. The PVP/PLLA blend solutions in various ratios were studied for electrospinning into ultrafine fibers. The morphology of the fibers was shown by scanning electron microscope (SEM). It wa...

Terminally differentiated somatic cells can rapidly change phenotypes when they are isolated from their native tissue and cultured in vitro. This problem may become a barrier to tissue engineering-based organ reconstruction, which utilizes somatic cells. The present study was designed to validate the feasibility of maintaining the urothelial cell phenotype in a tissue-specific ureteral scaffold...

We investigated the effects of the rate of solvent removal by varying ambient pressure at a fixed temperature on the morphology, particle sizes, drug encapsulation efficiency and releases pattern of lidocaine loaded poly-L-lactatide (PLLA) and poly-D,L-lactatide (PDLLA) microspheres, prepared with O/W emulsion–solvent evaporation process. Prepared in the fast rate of solvent evaporation (FRSE) ...

Infection caused by bacteria is one of the crucial risk factors for tendon adhesion formation. Silver nanoparticles (AgNP)-loaded physical barriers were reported to be effective in anti-infection and anti-adhesion. However, high silver load may lead to kidney and liver damages. This study was designed for Ibuprofen (IBU)-loaded poly(L-lactide) (PLLA) electrospun fibrous membranes containing a l...

The discipline of tissue engineering opens up the ways for repair and regenerate damaged organs and tissues. In the current work biomimetic nanofibrous scaffolds were fabricated by electrospinning. Poly-L-lactic acid (PLLA) was blended with collagen and gelatin to fabricate PLLLA-collagen and PLLA-gelatin fibrous scaffolds respectively. Pure PLLA and gelatin scaffolds served as controls. All th...

0014-3057/$ see front matter 2008 Elsevier Ltd doi:10.1016/j.eurpolymj.2008.06.002 * Corresponding author. Tel.: +86 451 82518 82518644. E-mail address: [email protected] (X. Lu). A new method of surface modification of TiO2 nanoparticles by surface-grafting L-lactic acid oligomer was developed. The surface-grafting reaction was evaluated by Fourier transformation infrared (FTIR) and thermal ...

The aim of the present study was to investigate the antitumor effects and tissue distribution of 32P-chromic-poly (L-lactide) (32P-CP-PLLA) in nude mice with human prostate cancer. Tumor models were obtained by transplantation of PC-3M tumor cells into male BALB/c nude mice. Animals were randomly divided into control, 32P-chromic phosphate (32P-CP) colloid and 32P-CP-PLLA groups (all n=20). A s...

Synthetic and natural polymer association is a promising tool in tissue engineering. The aim of this study was to compare five methodologies for producing hybrid scaffolds for cell culture using poly-l-lactide (PLLA) and collagen: functionalization of PLLA electrospun by (1) dialkylamine and collagen immobilization with glutaraldehyde and by (2) hydrolysis and collagen immobilization with carbo...

Introduction: Current cage devices considerably exceed the stiffness of the spinal segment, which may lead to stress-shielding, migration of the cage, and pseudarthrosis. In order to avoid these material related complications, a poly (L-lactic acid) cage device (PLLA cage) has been designed with limited stiffness compared to current cage devices and which will be absorbed on the long term. Biom...