Primary Myelofibrosis (PMF) is a chronic Philadelphia-negative myeloproliferative neoplasm characterized by a skewed megakaryopoiesis and an overproduction of proinflammatory and profibrotic mediators that lead to the development of bone marrow (BM) fibrosis. Since we recently uncovered the upregulation of miR-34a-5p in PMF CD34+ hematopoietic progenitor cells (HPCs), in order to elucidate its ...

We sought to determine the molecular basis for the anticancer activities of 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone (DH-PMF), isolated from Gardenia obtusifolia traditionally used in Thailand for a variety of ailments. As little as 1 μM DH-PMF inhibited the proliferation of prostate, colon, kidney, lung, head and neck, pancreas, breast, leukemia, and myeloma cancer cell lines. DH-PMF also...

Forget about farm-to-fork when it comes to genetically modified (GM) crops. Think farm-to-pharmacy, or farmto-factory. Produced through plant molecular farming (PMF), this new set of transgenic crops is being grown not for food, but to produce medicines and industrial products. For example, potatoes have been modified to produce a vaccine against the Norwalk virus, research that is currently in...

The aim of the present study was to predict pathogenic genes for primary myelofibrosis (PMF) using a system‑network approach by combining protein‑protein interaction (PPI) network and gene expression data with known pathogenic genes. PMF gene expression profiles, known pathogenic genes and protein‑protein interactions were obtained. Using these data, differentially expressed genes (DEGs) were i...

The classic -negative myeloproliferative neoplasms (MPNs), a form BCR-ABL of chronic malignant hemopathies, have been classified into polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). ET and PMF are two similar disorders in their pathogenesis, which is marked by a key role of the megakaryocyte (MK) lineage. Whereas ET is characterized by MK proliferation, ...

Even though mutations in epigenetic regulators frequently occur in myeloproliferative neoplasms, their effects on the epigenome have not been well studied. Furthermore, even though primary myelofibrosis (PMF) has a markedly worse prognosis than essential thrombocytosis or polycythemia vera, the molecular distinctions between these subgroups are not well elucidated. We conducted the HELP (HpaII ...

Extramedullary hematopoiesis (EMH) is a cardinal feature of primary myelofibrosis (PMF). The sites most frequently involved by EMH in PMF are the liver and spleen, leading to organ enlargement; however, many other organs have also been affected by EMH. Non-hepatosplenic EMH (NHS-EMH) has been reported in a multitude of tissues and organs, presenting as either an incidental finding or with sympt...

QoS prediction is critical to Web service selection and recommendation, with the extensive adoption of Web services. But as one of the important factors influencing QoS values, the geographical information of users has been ignored before by most works. In this paper, we first explicate how Probabilistic Matrix Factorization (PMF) model can be employed to learn the predicted QoS values. Then, b...

Background Primary myelofibrosis (PMF) is a myeloproliferative disorder resulting in progressive bone marrow fibrosis. In some PMF patients, a mutation in the gene coding for janus-associated kinase 2 (JAK2) results in cell proliferation and evasion of apoptosis. PMF typically occurs in older patients, and is associated with poor prognosis and low survival, with death occurring secondary to car...