We report here the responses of mice with symptomatic pneumovirus infection to combined antiviral and specific immunomodulatory agents. Mice infected with pneumonia virus of mice, a natural mouse pathogen that replicates the signs and symptoms of severe infection with respiratory syncytial virus (RSV), responded to the antiviral agent ribavirin when it was administered in the setting of endogen...

A serological survey was conducted to detect avian pneumovirus (APV) antibodies in commercial poultry birds in Grenada using a commercially available enzymelinked immunosorbent assay (ELISA) kit. Sera were collected from 226 layers and 233 broilers. Age of the layers ranged from 12 to 18 months while that of the broilers ranged from 6 to 7 weeks. One hundred forty of the layers (61.9%) and 74 o...

The respiratory syncytial (RS) viruses belong to the pneumovirus genus of the paramyxoviridae [65]. The virus genome is a single strand of negative sense R N A which is transcribed into ten major species of messenger RNA, each of which encodes a viral protein. Three glycoproteins are associated with the surface of the virion and the infected cell the a t tachment protein, G, the fusion protein,...

Feral swine are known reservoirs for various pathogens that can adversely affect domestic animals. To assess the viral ecology of feral swine in the USA, metagenomic sequencing was performed on 100 pooled nasal swabs. The virome was dominated by small, ssDNA viruses belonging to the families Circoviridae, Anelloviridae and Parvovirinae. Only four RNA viruses were identified: porcine kobuvirus, ...

Turkey rhinotracheitis, now commonly termed avian pneumovirus (APV) infection, is associated with serious welfare and economic problems in susceptible populations of turkeys and probably also of chickens. The infection principally affects the upper respiratory tract, although egg-laying performance may also be affected in breeding turkeys. Secondary infections exacerbate the effects of the prim...

Bovine respiratory syncytial virus (BRSV) is a pneumovirus in the family paramyxoviridae, is an important cause of acute respiratory disease in postweaning calves and feedlot cattle. The real-time reverse transcriptase PCR protocols were developed to detect BRSV infection in infected animals. The sensitivity of RT-PCR protocols based on fusion gene were evaluated using different Mastermixes suc...

Human metapneumovirus (HMPV) is a member of the subfamily Pneumovirinae within the family Paramyxo- viridae. Other members of this subfamily, respiratory syncytial virus and avian pneumovirus, can be divided into subgroups on the basis of genetic or antigenic differences or both. For HMPV, the existence of different genetic lineages has been described on the basis of variation in a limited set ...