This thesis describes the design and implementation of a planner/optimizer/executioner (POE) for the COntext INterchange (COIN) system, . The POE takes a contextmediated query from the Mediation Engine of the system and returns the results of the query to the user of the system. Since context-mediated queries are composed of sub-queries to multiple data-sources, the POE plans the execution orde...

BACKGROUND/AIMS Postoperative endophthalmitis (POE) is a rare but potentially devastating complication of modern cataract surgery. We examine whether the use of injectable intraocular lenses (IOLs) is associated with a lower rate of POE after cataract surgery compared with forceps-inserted foldable IOLs. METHODS A single-centre retrospective cohort study of 25 410 cataract operations was perf...

PURPOSE Drug delivery to treat diseases of the posterior segment of the eye, such as choroidal neovascularization and its complications, is hampered by poor intraocular penetration and rapid elimination of the drug from the eye. The purpose of this study was to investigate the feasibility and tolerance of suprachoroidal injections of poly(ortho ester) (POE), a bioerodible and biocompatible poly...

We associate to a Hausdorff space, X, a double groupoid, ρ 2 (X), the homotopy double groupoid of X. The construction is based on the geometric notion of thin square. Under the equivalence of categories between small 2-categories and double categories with connection given in [BM] the homotopy double groupoid corresponds to the homotopy 2-groupoid, G2(X), constructed in [HKK]. The cubical natur...

We consider the problem of verifying MPI using MPI_Waitany (and related operations wait/test some/all). Such programs have a higher degree of non-determinism over which user-written test harnesses cannot exert adequate control. This makes conventional MPI program testing even more ineffective. Our previous work has demonstrated the advantages of an MPI-specific dynamic partial order reduction a...

Epilepsy is one of the main causes of functional disability, and it is usually associated to psychiatric comorbidity, such as psychosis of epilepsy (POE). POE requires more careful pharmacological treatment, considering the propensity of the antipsychotics (AP) to provoke seizures and the risk of pharmacokinetic interaction with anti-epileptic drugs (AEDs). We discussed the classification and t...

Modern cataract surgery with implantation of an intraocular lens (IOL) is an increasingly safe and successful procedure, though complications still occur. This thesis addresses the most common complication, posterior capsule opacification (PCO) and the rare but serious complication postoperative endophthalmitis (POE). The pathogenesis of PCO is multifactorial and several surgical and IOL-relate...

Suppose G is a second countable, locally compact, Hausdorff groupoid with a fixed left Haar system. Let G/G denote the orbit space of G and C∗(G) denote the groupoid C∗-algebra. Suppose that G is a principal groupoid. We show that C∗(G) is CCR if and only if G/G is a T1 topological space, and that C∗(G) is GCR if and only if G/G is a T0 topological space. We also show that C∗(G) is a Fell Algeb...

In this paper S will denote an AG-groupoid. A two-sided ideal I of S is called a right (left) pure ideal of S , if for each x in I , there is an element y in I such that ) = ( = x yx x xy . A left (right) pure ideal I is called purely prime if it is proper and if for any pure ideals 1 I and 2 I : I I I 2 1 implies I I1 or I I2 . Analogous to the construction of the pure spectrum of a semigroup ...

In this note a functorial approach to the integration problem of an LAgroupoid to a double Lie groupoid is discussed. To do that, we study the notions of fibered products in the categories of Lie groupoids and Lie algebroids, giving necessary and sufficient conditions for the existence of such. In particular, it turns out, that the fibered product of Lie algebroids along integrable morphisms is...