Cardiotonic steroids (CTS) are clinically important drugs for the treatment of heart failure owing to their potent inhibition of cardiac Na(+), K(+)-ATPase (NKA). Bufadienolides constitute one of the two major classes of CTS, but little is known about how they interact with NKA. We report a remarkable stereoselectivity of NKA inhibition by native 3β-hydroxy bufalin over the 3α-isomer, yet repla...

Cells of Sulfolobus acidocaldarius contain about 2.5% total lipid on a dry-weight basis. Total lipid was found to contain 10.5% neutral lipid, 67.6% glycolipid, and 21.7% polar lipid. The lipids contained C(40)H(80) isopranol glycerol diethers. Almost no fatty acids were present. The glycolipids were composed of about equal amounts of the glycerol diether analogue of glucosyl galactosyl diglyce...

The neural basis of pattern recognition is a central problem in visual neuroscience. Responses of single cells were recorded in area V4 of macaque monkey to three classes of periodic stimuli that are based on spatial derivative operators: polar (concentric and radial), hyperbolic, and conventional sinusoidal (Cartesian) gratings. Of 118 cells tested, 16 percent responded significantly more to p...

The photoinduced alignment of a liquid crystal (LC) on films of azo dyes was studied for the liquid crystal display applications. In order to improve the alignment stability of the photoaligned dye (SD-1), the azo-dye derivative with polymerizable terminal groups was synthesized (SDA-1). The films of SDA-1 exhibit good photoalignment properties and ultraviolet stability after thermal polymeriza...

Non-flagellate H2 mutants were isolated from a phase-2 stable strain, SJW806 H1-gt- H2-enxon vh2-, a derivative of Salmonella typhimurium. By transductional crosses a deletion map and a recombination map of the H2 gene were made. There are three regions especially rich in nonflagellate mutational sites. By the use of the deletion map, mutational sites of 21 flagellar shape mutants were also det...

Kinetic and thermodynamic properties of water encapsulation from organic solution by an open-cage [60]fullerene derivative have been investigated. 2D exchange NMR spectroscopy (EXSY) measurements were employed to determine the association and dissociation constants at 300-330 K (k(a) = 4.3 M(-1) × s(-1) and k(d) = 0.42 s(-1) at 300 K) in 1,1,2,2-tetrachloroethane-d(2) as well as the activation ...

In this laboratory exercise we will measure the equilibrium constant for the cis-trans isomerism about a peptide bond involving the amino acid L-Proline. This will be accomplished by determining the relative concentrations of each isomer using key proton signals in a Nuclear Magnetic Resonance (NMR) spectrum of a solution of an N-Acetyl derivative of the amino acid, which will serve as a model ...

the present study aims at indicating the existence and uniqueness result of system in extended colombeaualgebra. the caputo fractional derivative is used for solving the system of odes. in addition, rieszfractional derivative of colombeau generalized algebra is considered. the purpose of introducing rieszfractional derivative is regularizing it in colombeau sense. we also give a solution to a n...

Investigation of the non-polar (rich in chlorophyll) and polar fractions ethyl acetate extract Gymnosporia senegalensis (Lam.) Loes. leaves led to isolation nine compounds, including one new megastigmane derivative, (3 R*,5 S*,6 R*,7 E,9ξ)-7-megastigmene-3,6,9-triol-3- O-β-D-(6′- O-galloyl)glucopyranoside (1), four known galloylated derivatives (2, 3, 8, 9), three chlorophyll (4–6), fatty acid ...

Many image-rotation invariant texture classification approaches have been presented. However, image rotation is not necessarily the same as surface rotation. This paper proposes a novel scheme that is surface-rotation invariant. It uses magnitude spectra of the partial derivatives of the surface obtained using photometric stereo. Unfortunately the partial derivative operator is directional. It ...