Kinetin is a highly potent growth factor that is capable of delaying or preventing age-related changes of human skin fibroblasts. The purpose of this study was to develop and characterize topical kinetin-loaded emulsion gel and liposome gel formulations. Emulsion formulation was prepared using the spontaneous emulsification method. Pseudoternary phase diagram for oil/water (o/w) type emulsion w...

The main objective of this study is to formulate Bromfenac Microemulsion with prolonged duration of action which will help in increasing its topical bioavailability. Bromfenac belongs to the category of NSAID. A calibration curve of Bromfenac was taken in USP Phosphate buffer pH 7.4 at 268nm. Oleic acid, Poloxamer 188 and Propylene glycol were found to have maximum absorbance during solubility ...

DNA-complexes with platelet-like, cationically modified lipid nanoparticles (cLNPs) are studied with regard to the formation of nanocomposite structures with a sandwich-like arrangement of the DNA and platelets. For this purpose suspensions of platelet-like triglyceride nanocrystals, stabilized by a mixture of two nonionic (lecithin plus polysorbate 80 or poloxamer 188) and one cationic stabili...

The aim of this study was the evaluation of the effects of two emulsifiers on the physicochemical and technological properties of low molecular weight chitosan/poly (D,L-lactide-co-glycolide) (PLGA) nanoplexes and their transfection efficiency. Nanospheres were prepared using the nanoprecipitation method of the preformed polymer. The mean diameter and surface charge of the nanospheres were inve...

In this paper, the optimal composition of a paeonol temperature-sensitive in situ gel composed of poloxamer 407 (P407) was determined, and a preliminary study of its effect on allergic rhinitis was performed. The optimal composition of the paeonol temperature-sensitive in situ gel included 2% paeonol inclusion, 22% P407, 2% poloxamer 188 (P188) and 2% PEG6000, as assessed by thermodynamic and r...

BACKGROUND Skeletal muscle injury can result in significant edema, which can in turn lead to the development of acute extremity compartment syndrome (CS). Poloxamer-188 (P-188), a multiblock copolymer surfactant, has been shown to decrease edema by sealing damaged membranes in a number of tissues after a variety of injury modalities. The objective is to determine whether the administration of P...