in this study, doxycycline hyclate release behavior from in situ forming drug delivery systems investigated. these systems based on poly()lactide-co-glycolide)(50:50 dissolved in n-methyl-2-pyrrolidone that were evaluated in different concentrations. these systems are useful for local treatment of periodontal diseases. uv spectroscopy is used to determine drug concentration in release medium. a...

membrane permeability and p-glycoprotein (p-gp) efflux system are regulating factors in the drug brain penetration. recently, some drug delivery systems have been developed to overcome these limitations. in this study, metoclopramid has been encapsulated in plga nanoparticles using the emulsification/solvent evaporation technique for in vitro evaluation of the effect of plga nanoparticles on bb...

Fabrication of novel bio-supramolecular structures was achieved by recrystallizing the bacterial surface protein SbpA on amorphous and semicrystalline polylactide derivatives. Differential scanning calorimetry showed that the glass transition temperature (T(g)) for (poly-L-lactide)-PLLA, poly(L,D-lactide)-PDLLA, poly(lactide-co-glycolide)-PLGA and poly(lactide-co-caprolactone)-PLCL was 63 °C, 5...

We present a comparison of the influence conditioning temperature microspheres made medical grade poly(L-lactide) (PLLA) and polylactide with 4 wt % D-lactide content (PLA) on thermal structural properties. The were fabricated using solid-in-oil-in-water method for applications in additive manufacturing. annealed below glass transition (Tg), above Tg but onset cold crystallization, at two tempe...

There are increasing numbers of developed nanocarriers for anticancer drug delivery in the aim to avoid side effects conventional chemotherapy. Filomicelles with folic acid (FA) as a targeting moiety novel approach that can potentially maximize therapeutic efficacy while minimizing effects. The this study was analyze influence composition PLA-based micelles functionalized on their encapsulation...