objective concern for side-effects of therapy related to treatment of childhood malignancies is becoming an increasingly important topic. in this study, we evaluated extent of vincristine (vcr) induced neurotoxicity in a group of children who underwent chemotherapy, with vcr being part of the regimen. materials & methods in this investigation, for 75 children (54% boys, 46% girls), aged between...

Introduction: Cardiovascular autonomic neuropathy (CAN) is a common and one of the major complication diabetes mellitus. It also most under diagnosed least understood diabetic complication4. Objective: To determine frequency cardiac its various grades in type 2 Study Design: Cross Sectional Study. Setting: Medical OPD as well from clinic Services Hospital, Lahore. Methodology: Total 195 patient...

Role of the innate immune system in the pathogenesis of multiple sclerosis. et al. Rituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trial. Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Retland E, et al. Differential effects of Th1...

nanofibrous scaffolds produced by electrospinning have attracted much attention, recently. aligned and random nanofibrous scaffolds of poly (vinyl alcohol) (pva), poly (ε-caprolactone) (pcl) and nanohydroxyapatite  (nha) were fabricated by electrospinning method in this study. the composite nanofibrous scaffolds were subjected to detailed analysis. morphological investigations revealed that the...

intracranial hemorrhage and entrapment neuropathy are the most serious and disabling complications in hemophilia.the occurance of these neurological complications was studied in 214 hemophiliac patients during a 3 month period. nine patients (4.2%) suffered intracranial hemorrhage (one epidural and others intracerebral). all of intracranial hemorrhage patients had the sevee form of disease (<1%...

the use of manometry, i.e. the recording of pressures within hollow viscera, after being successfully applied to the study of esophageal and anorectal motor dysfunctions, has also been used to investigate physiological and pathological conditions of the small bowel. by means of this technique, it has been possible to understand better the normal motor functions of the small intestine, and their...

objective: diabetes mellitus is one of the most common endocrine diseases with micro-vascular complications and is a common cause of polyneuropathy. we studied the effect of enalapril on electrophysiologic criteria and clinical symptoms of patients with type ii diabetes and sensory neuropathy. materials and methods: a double blind study was conducted on 45 patients with type ii diabetes and neu...

conclusions although toxoplasmosis nr is rare, it should be considered in the differential diagnoses of nr. case presentation a 13-year-old girl presented with painless subacute visual loss in her right eye for a week at khatam-al-anbia eye hospital in mashhad, iran. following comprehensive evaluation, a diagnosis of toxoplasmic nr was made. the nr favorably responded to classic anti-toxoplasmo...

OBJECTIVE Impairment of skin quality may contribute to diabetic foot ulceration (DFU). Our goal was to determine whether high-risk patients exhibited specific skin structural and metabolic deficits that could predispose to foot complications. RESEARCH DESIGN AND METHODS A total of 46 patients comprising 9 diabetic control subjects, 16 with diabetic peripheral neuropathy (DPN) alone, and 21 wi...