In many instances pharmacokinetic modeling offers the best method of interpreting the significance to man of results obtained with laboratory animals but first we must have accurate models for our laboratory animals. A physiological pharmacokinetic model has been used to simulate the disposition of polychlorinated biphenyls (PCBs) in the rat and to extrapolate results obtained with the rat to p...

Title:Potential effects of polychlorinated biphenyls (PCBs) and selected organochlorine pesticides (OCPs) on immune cells and blood biochemistry measures (NHANES 2003-2004)

Antibodies against cytochromes P-450a, P-450b + P450e, P-450c, and P-450d and epoxide hydrolase were utilized in a radial immunodiffusion assay to measure the concentration of these inducible, xenobiotic-metabolizing enzymes in liver microsomes from rats treated with Aroclor 1254, fireMaster BP-6, or one of 41 individual polychlorinated and polybrominated biphenyl isomers and congeners. Cy...

In accordance with waste strategy for Turkey, the study was carried out to analyses waste engine crankcase oils and waste gearbox oils generated from vehicle maintenance services in order to determine their suitability for recycling, recovery or final disposal based on regulation published by Turkish Ministry of Environment and Forestry on 21 January 2004. The regulation requires all waste oil ...