In the present work, levofloxacin based microemulsion was developed and its usefulness as topical drug carrier system for anti bacterial activity was investigated. Microemulsion was prepared by phase titration method using oleic acid as oil phase, tween-60 as surfactant and isopropyl alcohol as co-surfactant. Five different formulations were formulated with various amount of the oil, water and ...

The aim of the present study was to prepare, characterize and in-vitro evaluation of a Winsor-IV type microemulsion based drug delivery system incorporating celecoxib as BCS class–II model drug. Attempts were made to prepare cost effective O/W microemulsion using Tween 80, Glycerol, sunflower oil and water. The existence of microemulsion zone was investigated using phase diagrams. The systems w...

Topical microemulsion systems for the antiacne agent, nadifloxacin were designed and developed to overcome the problems associated with the cutaneous delivery due to poor water solubility. The solubility of nadifloxacin in oils, surfactants and cosurfactants was evaluated to screen the components of the microemulsion. Various surfactants and cosurfactants were screened for their ability to emul...

Polyprenol (GBP) from Ginkgo biloba Leaves (GBL) is an important lipid with many bioactive effects. The effect of GBP on antibacterial properties of five antibiotics belonging to different classes was through analysis of inhibition halos, MIC, and FIC index. And we studied the time-killing curves and Ca(2+) mobilization assay in Staphylococcus aureus cells treated with GBP microemulsion and gen...

This study evaluated the potential of poly(iso-butyl cyanoacrylate) (PBCA) nanocapsules dispersed in a biocompatible microemulsion to facilitate the absorption of insulin following intragastric administration to diabetic rats. Insulin-loaded PBCA nanocapsules were prepared in-situ in a biocompatible water-in-oil microemulsion by interfacial polymerisation. The microemulsion consisted of a mixtu...

The objective of this study was to develop an oral microemulsion formulation of the antitumor diterpenoid agent, ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid (henceforth referred to as 5F), to enhance its bioavailability and evaluate its hepatotoxicity. Pseudoternary phase diagrams showed that the optimal microemulsion formulation contained 45% water, 10% castor oil as the oil phase, 15% Cremo...

In this paper we investigate the receipt of cadmium sulfide nanoparticles in the microemulsion system stabilized by nonionic surfactants, and the effect of the volume of microemulsion droplets and supersaturation on the size of the particles formed CdS. The photoluminescence spectrum microemulsion system containing nanoparticles of CdS, is shifted to shorter wavelengths of the spectrum and the ...

The finite-wavelength instability gives rise to a new type of wave in reaction-diffusion systems: packet waves, which propagate only within a wave packet, are found in experiments on the Belousov-Zhabotinsky reaction dispersed in water-in-oil AOT microemulsion (BZ-AOT) as well as in model simulations. Inwardly moving packet waves with negative curvature occur in experiments and in a model of th...

Ion transport of multi-ionic solutions through layered electrolyte and polyelectrolyte structures are relevant in a large variety of technical systems such as micro and nanofluidic devices, sensors, batteries and large desalination process systems. We report a new direct numerical simulation model coined EnPEn: it allows to solve a set of first principle equations to predict for multiple ions t...

The multistep procedures for preparing novel anionic spherical polyelectrolyte brushes (ASPB) by grafting sodium-p-styrenesulfonate (SSS) from the surface of !-methacryloxypropyl trimethoxy-silane modified SiO2 nanoparticles were demonstrated. The morphology of ASPB was characterized by Transmission Electron Microscopy (TEM) and Scanning Electron Microscopy (SEM). The core radius Rc and hydrody...