نتایج جستجو برای: polyelectrolytemodified microemulsion

تعداد نتایج: 1878  

Hirenkumar Kukadiya Naazneen Surti, Rajshree Mashru Surjyanarayan Mandal Vandana Patel

Clopidogrel, an inhibitor of platelet aggregation, selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Oral bioavailability of clopidogrel is very low (less than 50%), due to its poor water solubility. The aim of this investigation was ...

Hirenkumar Kukadiya Naazneen Surti, Rajshree Mashru Surjyanarayan Mandal Vandana Patel

Clopidogrel, an inhibitor of platelet aggregation, selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Oral bioavailability of clopidogrel is very low (less than 50%), due to its poor water solubility. The aim of this investigation was ...

Journal: :iranian journal of pharmaceutical research 0
seyed alireza mortazavi department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. sanaz pishrochi department of pharmaceutics, pharmaceutical sciences branch, islamic azad university, tehran, iran. zahra jafari azar department of pharmaceutics, pharmaceutical sciences branch, islamic azad university, tehran, iran.

in this study, tretinoin microemulsion has been formulated based on phase diagram studies by changing the amounts and proportions of inactive ingredients, such as surfactants, co-surfactants and oils. the effects of these variables have been determined on microemulsion formation, particle size of the dispersed phase and release profile of tretinoin from microemulsion through dialysis membrane. ...

2013
Rashmin B. Patel Mrunali R. Patel Kashyap K. Bhatt Bharat G. Patel

This paper describes formulation considerations and in vitro evaluation of an oleic acid-based polyelectrolytic polymer-containing microemulsion drug delivery system designed for intranasal administration of a hydrophobic model drug Olanzapine. Drug-loaded microemulsions were successfully prepared by a water titration method. The microemulsion containing 4% oleic acid, 30% surfactant mixture of...

Journal: :Journal of oleo science 2012
Said Fatouh Hamed Zainab Sadek Amr Edris

Clove bud essential oil (CEO) and its major individual phenolic constituent eugenol were formulated as nanoparticles in water-based microemulsion systems. The oil titration method was used to incorporate different amounts of the oil and eugenol in the micellar solution of Tween-20. The Antioxidant and antimicrobial activities were evaluated using the DPPH* free radical scavenging assay and the ...

Journal: :Journal of colloid and interface science 2007
Qingde Chen Xinghai Shen Hongcheng Gao

A local ordered structure constructed from solid Cu(2)O nanocubes was obtained by the radiolytic reduction of Cu(NO(3))(2) in a water-in-oil (W/O) microemulsion composed of Triton X-100, n-hexanol, cyclohexane, and water in the presence of ethylene glycol (EG). However, when Triton X-100 was replaced with Brij 56 in the microemulsion, hollow Cu(2)O nanocubes were synthesized. The addition of to...

Journal: :Chemical & pharmaceutical bulletin 2016
Eon-Pyo Hong Ju-Young Kim Su-Hyeon Kim Kyu-Mok Hwang Chun-Woong Park Hyo-Jung Lee Dong-Wook Kim Kwon-Yeon Weon Seo Young Jeong Eun-Seok Park

The purposes of the present study were to develop a self-microemulsifying drug delivery system (SMEDDS) containing bortezomib, a proteasome inhibitor. The solubility of the drug was evaluated in 15 pharmaceutical excipients. Combinations of oils, surfactants and cosurfactants were screened by drawing pseudo-ternary phase diagrams. The system exhibiting the largest region of microemulsion was co...

2014
Albert Serrà Manuel Montiel Elvira Gómez Elisa Vallés

A new electrochemical method to synthesize mesoporous nanowires of alloys has been developed. Electrochemical deposition in ionic liquid-in-water (IL/W) microemulsion has been successful to grow mesoporous CoPt nanowires in the interior of polycarbonate membranes. The viscosity of the medium was high, but it did not avoid the entrance of the microemulsion in the interior of the membrane's chann...

Journal: :Molecules 2017
Jianmei Pang Wujun Dong Yuhuan Li Xuejun Xia Zhihua Liu Huazhen Hao Lingmin Jiang Yuling Liu

Essential oil extracted from Houttuynia cordata Thunb. (H. cordata) is widely used in traditional Chinese medicine due to its excellent biological activities. However, impurities and deficient preparations of the essential oil limit its safety and effectiveness. Herein, we proposed a strategy to prepare H. cordata essential oil (HEO) safely and effectively by combining the solvent extraction an...

Jianxue Yang Liandong Hu Qiaofeng Hu,

Objective(s):The objective of this study was to find a stable microemulsion vehicle for transdermal delivery of ibuprofen to improve the skin permeability. Materials and Methods: Microemulsion was prepared using different sorts of oils, surfactants and co-surfactants. Pseudo-ternary phase diagrams were used to evaluate the microemulsion domain. The effects of oleic acid and surfactant mixture o...

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