To investigate a nuclear factor-kappa B decoy oligonucleotides strategy on the inhibition of tissue factor (TF) expression in cultured rat brain microvascular endothelial cells (BMECs) by polylactic acid (PLA) nanoparticles delivery system and to evaluate this new vector for in vitro gene therapy. Nanoparticles were formulated using poly D,L-polylactic acid with surface modifying by polysorbate...

A versatile and straightforward strategy to functionalize biomaterials is described. This click chemistry-based methodology was successfully used polylactic acid, gold titanium surfaces.

The microbial degradation behavior of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) and its compound with several polyesters such as poly(butylene adipate-co-telephtharate) (PBAT), poly(butylene succinate) (PBS), and polylactic acid (PLA) in seawater was tested by a biological oxygen demand (BOD) method. PHBHHx showed excellent biodegradation in seawater in this study. In addition, the...

Introduction Biodegradable stents have the potential to avoid long-term complications of conventional stents such as in-stent restenosis and late stent thrombosis, and could allow for a restoration of vasomotion and vessel growth which makes them suitable for e.g. paediatric applications [1]. To investigate the mechanics of this new type of stent via finite element simulations, we developed a n...

An endogenous depolymerization model based on uniform weight distribution is introduced. The time dependent model with temporal dependent degradation rate is reduced to a time independent model. The previously developed techniques were applied to an inverse problem to determine the degradation rate. The transition of weight distribution was simulated by solving an initial value problem. Those t...

Polylactic acid (PLA) was successfully covalently grafted onto multi-walled carbon nanotubes (MWCNT) by microwave-assisted polymerization of lactide monomers. The final products MWCNT-g-PLA were characterized with Fourier-transform IR (FTIR), Raman spectroscopy, thermogravimetric analyses (TGA) and transmission electron microscopy (TEM). The results indicated PLA chain was covalently attached t...

In natural world, lignin is unique and the most abundant renewable carbon source after cellulose, therefore, more applications of adding commercial value of lignin are needed. Polylactic acid (PLA), which has the second highest consumption of bioplastic in the world, is a biodegradable composite with widely application in industry. A filler adding into PLA can decrease the cost of the composite...

PURPOSE To investigate the possibility of using polylactic acid (PLA) as a surgical adjuvant for visualizing the vitreous body during vitrectomy. METHODS After a core vitrectomy, 1 mL of PLA suspension was injected into the rabbit vitreous in two groups: group A, 2.5% PLA (n = 5), and group B, 1% PLA (n = 9). Vehicle injection instead of PLA was used as a control (group C, n = 5). The clinica...

This work presents the experimental steps taken towards preparation of 3D printable bionanocomposites using polylactic acid (PLA) biopolymer containing 0.1, 0.5 and 1 wt% CNCs.