To determine if anodal excitation during bipolar stimulation facilitates the initiation of sustained monomorphic ventricular tachycardia, nonsustained polymorphic ventricular tachycardia, or repetitive ventricular responses, both bipolar and cathodal unipolar programmed ventricular stimulation with one to three extrastimuli delivered during ventricular pacing at two rates from the right ventric...

KEY POINTS The mechanism of therapeutic efficacy of flecainide for catecholaminergic polymorphic ventricular tachycardia (CPVT) is unclear. Model predictions suggest that Na(+) channel effects are insufficient to explain flecainide efficacy in CPVT. This study represents a first step toward predicting therapeutic mechanisms of drug efficacy in the setting of CPVT and then using these mechanisms...

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a highly lethal form of inherited arrhythmogenic disease characterized by adrenergically mediated polymorphic VT. The identification of the genetic substrate of the disease has allowed to achieve important milestones in the understanding of the arrhythmogenic mechanisms of the disease. Abnormal calcium leak from the mutant cardiac ...

RATIONALE Flecainide prevents arrhythmias in catecholaminergic polymorphic ventricular tachycardia, but the antiarrhythmic mechanism remains unresolved. It is possible for flecainide to directly affect the cardiac ryanodine receptor (RyR2); however, an extracellular site of action is suggested because of the hydrophilic nature of flecainide. OBJECTIVE To investigate the mechanism for the anti...

Electrical storm (ES) is not a rare clinical entity. Sympathetic hyperactivity may play critical role in development and continuation of ES. Some recent reports have demonstrated that catheter-based renal sympathetic denervation (RSD) may reduce sympathetic activation and have a potential role in reducing arrhythmic burden. A 46-year-old man was admitted to clinic with frequent implantable card...

this study evaluates the discriminative power of sequential spectrum analysis of the short-term electrocardiogram (ecg) time series in separating normal and subjects with life threatening arrhythmias like, ventricular tachycardia/fibrillation (vt/vf). the raw ecg time series is transformed into a series of binary symbols and the binary occupancy or relative distribution of mono-sequences (i.e. ...

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia characterized by adrenergically induced polymorphic or bidirectional ventricular tachycardia (VT). Although a rare disease, its recognition is important because of its high mortality rate when left untreated. We report an index case of a 32-year-old woman who presented with recurrent syncope. The diagnosis w...

Case report An 8 year-old boy had been treated for 2 years for exerciserelated “seizures” unresponsive to phenobarbital and levetiracetam. He presented to an outside hospital after an episode of loss of consciousness while playing laser tag. The episode was thought to be a seizure but lasted 45 minutes, so Emergency Medical Services was called. When Emergency Medical Services arrived, he was in...

the aim of this study is to evaluate how far lempel-ziv complexity (lzc) of the binary symbolic sequences resulting from static or dynamic transformation (partitioning first-order difference) of the short-term electrocardiogram (ecg) signals (only 2 seconds duration) has the  potential in discriminating normal and ventricular tachycardia/ventricular fibrillation (vt/vf) subjects. the statistica...