Recent fMRI and fTCD studies have found that functional modules for aspects of language, praxis, visuo-spatial functioning, while typically left, left right hemispheric respectively, frequently show atypical lateralisation. Studies with increasing numbers participants are finding module combinations, which here termed cerebral polymorphisms—qualitatively different lateral organisations cognitiv...

There are many immune mediated disorders with the corroborated role of vitamin D or Vitamin D Receptor (VDR) gene polymorphisms in their pathogenesis, immunologic regulation, and disease characteristics. Therefore, in this review, we searched PubMed data base in regard to the role of VDR gene polymorphisms in common autoimmune disorders, emphasizing on dermatologic diseases.

background: polycystic ovary syndrome (pcos) is a complex disease having both genetic and environmental components and candidate genes on obesity and insulin metabolism have been hypothesized to be involved in its etiology. objective: we examined the possible association of adiponectin and insulin receptor gene polymorphisms with pcos. materials and methods: a total of 186 women with pcos using...

aim :  to evaluate the association of dnmt1 and mgmt amino acid substitution polymorphisms and colorectal cancer in iranian population. background : the mgmt and dnmt1 are two important methyltransferase enzymes. amino acid substitution polymorphisms in mgmt and dnmt1 genes may be associated with the genetic susceptibility to sporadic colorectal cancer. patients and methods : we assessed eight ...

Infertility as a vital process in human reproduction involves many couples worldwide. Although many genetic causes of infertility are known, the genetic basis of infertility in men is largely unknown. Therefore, the identification of genetic biomarkers in this field is important and genetic polymorphisms in key genes of the spermatogenesis pathway can be valuable biomarkers in this field. Gene'...

Background: In the pathogenesis of inflammatory bowel disease (IBD), the advanced glycation end product receptor (RAGE) has been involved. IBD is classified into Chron’s disease (CD) and ulcerative colitis (UC). The promoter gene of the RAGE gene was discovered to have had unique polymorphisms that increased its transcriptional activity. This study, therefore, used a systematic review and meta-...

The avianuncoupling protein (avUCP) is a member of the mitochondrial transporter superfamily that uncouples proton entry in the mitochondrial matrix from ATP synthesis. The polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method was used to estimate the allele and genotype frequencies of the UCP/HhaI polymorphisms and to determine associations between these polymorp...

Background Spontaneous abortion has been defined as two or more consecutive miscarriages at 20 weeks pregnancy. Vascular endothelial growth factor (VEGF) plays a main role in fetal and placental angiogenesis which secretes from different cells like endometrium and placenta.The objective of this study was to investigate of association of VEGFA gene polymorphisms and recurrent spontaneous abortio...

uterine leiomyoma (ul) is the most common benign smooth muscle cell tumor with as yet unknown etiology and pathogenesis. this study was carried out to investigate the association of esr1-351 a>g, esr1 -397 t>c and cyp1a1 (ile462val) polymorphisms with ul in female patients of iranian origin. in this case-control study, 276 patients with ul and 156 healthy women were recruited. the genetic polym...