fibrous dysplasia of the bone (fdb) is a common, genetic, developmental disorder with a benign course. fdb can be seen anywhere throughout the skeleton. it is usually asymptomatic and found incidentally on imaging studies that are performed for other purposes. although whole body 18 f-flourodeoxyglucose pet/ct (fdg pet/ct) is widely used in tumor imaging, infections and benign pathologies like ...

Paget’s disease of bone (PD) is a monostotic or polyostotic non-hormonal osteometabolic disorder. Over a century after the original disease was described by Sir John Paget in 1877, and despite recent intensive studies and widespread interest, its aetiology remains obscure. This review describes the pathomechanism of the structural changes which occur in bone affected with PD, induced by the dif...

Polyostotic fibrous dysplasia (FD) associated to McCune-Albright Syndrome (MAS) often leads to fractures, deformities, and bone pain resulting in bad quality of life. Parenteral bisphosphonates have been used in children and adolescents to improve these symptoms with few adverse effects. We evaluated the response to oral Alendronate in a girl with severe MAS FD and observed improved quality of ...

A 35-year-old man with polyostotic fibrous dysplasia and a massively enlarged skull presented with Lhermitte sensations due to an unstable, mulitseptated, lytic C2/3 vertebral body complex. Enlarged extracranial vasculature made open surgery a high-risk option and limited percutaneous access. A 5F catheter was directed by using a guidewire into the C2/C3 vertebral body complex via a transpedicu...