The desired objective of controlled ovarian stimulation (COS) is to allow the growth of a cohort of follicles and to facilitate the recovery of a large number of fertilizable oocytes. However, poor responders with low ovarian reserve often fail to respond adequately despite the maximal dose of gonadotropins administered, with the results that the number as well as quality of oocytes harvested m...

Address for Correspondence / Yazışma Adresi: Uzm. Dr. Huriye Ayşe Parlakgümüş, Başkent Üniversitesi Seyhan Uygulama Hastanesi, Cemal Paşa Mah. Barajyolu, 01110 Adana, Turkey Phone: +90 322 458 68 68/2203 e.mail: [email protected] doi:10.5152/jtgga.2011.01 Objective: To investigate whether pregnancy complications are increased in poor responders to ovarian stimulation in IVF treatment. Ma...

OBJECTIVES We evaluated the prevalence and mechanism of poor responsiveness to clopidogrel and prasugrel in coronary artery disease patients with and without diabetes. BACKGROUND Low platelet inhibition by clopidogrel is associated with ischemic clinical events. A higher 600-mg loading dose (LD) has been advocated to increase responsiveness to clopidogrel. METHODS In this study, 110 aspirin...

Interindividual variability in low density lipoprotein (LDL) cholesterol (LDL-C) response during treatment with statins is well documented but poorly understood. To investigate potential metabolic and genetic determinants of statin responsiveness, 19 patients with refractory heterozygous familial hypercholesterolemia were sequentially treated with placebo, atorvastatin (10 mg/d), bile acid sequ...

background: our objective was to evaluate the effectiveness of clomiphene citrate (cc) vs. letrozole (l) plus human menopausal gonadotropin (hmg) in gonadotropin releasing hormone (gnrh) antagonist protocol in poor prognosis women with previous failed ovarian stimulation undergoing intracytoplasmic sperm injection (icsi). materials and methods: this retrospective cohort study included cycles wi...

BACKGROUND The aim of this meta-analysis was to evaluate the role of androgens or androgen-modulating agents on the probability of pregnancy achievement in poor responders undergoing IVF. METHODS Medline, EMBASE, CENTRAL, Scopus and Web of Science databases were searched for the identification of randomized controlled trials evaluating the administration of testosterone, dehydroepiandrosteron...