There is a significant evidence indicating that pores of nanoscopic dimensions can stochastically form and grow in a lipid bilayer of a cell membrane following an activated process induced by an external trigger such as thermal fluctuations, transmembrane electrical potential, mechanical stress or other changes in the cellular environment. In this review article, we present an overview of recen...

Hydrocarbon traps can be used to bridge the temperature gap from cold start of a vehicle until exhaust after-treatment catalyst has reached its operating temperature. In this work, we investigate effect zeolite structure (ZSM-5, BEA, SSZ-13) and La addition H-BEA H-ZSM-5 on hydrocarbon storage capacity by temperature-programmed desorption DRIFT spectroscopy. The results show that presence signi...

Dendrimers are unique highly branched macromolecules with numerous groundbreaking biomedical applications under development. Here we identified poly(amido amine) (PAMAM) dendrimers as novel blockers for the pore-forming B components of the binary anthrax toxin (PA63) and Clostridium botulinum C2 toxin (C2IIa). These pores are essential for delivery of the enzymatic A components of the internali...

The cystic fibrosis (CF) transmembrane conductance regulator (CFTR) is a member of the ATP-binding cassette transporter superfamily that functions as an epithelial chloride channel. Gating of the CFTR ion conduction pore involves a conserved irreversible cyclic mechanism driven by ATP binding and hydrolysis at two cytosolic nucleotide-binding domains (NBDs): formation of an intramolecular NBD d...

The traditional consideration of architectural history as a linear process, where one style successively replaces another, still dominates, but does not explain many phenomena. V.S. Goryunov substantiated fundamentally different, non-linear model the historical process in architecture on basis 19th – early 20th centuries. V. S. and M. P. Tubli proposed stylistic polyphony with introduction conc...

Whereas the two-phase commit protocol guarantees global atomicity, its biggest drawback is that it is a blocking protocol whenever the coordinator fails, cohort sites will have to wait for its recovery. Although threephase commit protocol was devised to reduce blocking situation, it increases latency. In this paper we propose a proxy based two-phase atomic commitment protocol to improve the per...

Ion channel block in muscle acetylcholine nicotinic receptors (AChRs) is an extensively reported phenomenon. Yet, the mechanisms underlying the interruption of ion flow or the interaction of the blocker with the channel's gates remain incompletely characterized. In this paper, we studied fast channel block by choline, a quaternary-ammonium cation that is also an endogenous weak agonist of this ...

Many pathogens utilize the formation of transmembrane pores in target cells in the process of infection. A great number of pore-forming proteins, both bacterial and viral, are considered to be important virulence factors, which makes them attractive targets for the discovery of new therapeutic agents. Our research is based on the idea that compounds designed to block the pores can inhibit the a...