PURPOSE Posterior capsular opacification (PCO), the most prevalent side effect of cataract surgery, occurs when residual lens epithelial cells (LECs) undergo fiber cell differentiation or epithelial-to-mesenchymal transition (EMT). Here, we used a murine cataract surgery model to investigate the role of the Zeb proteins, Smad interacting protein 1 (Sip1) and δ-crystallin enhancer-binding factor...

nd:yag laser capsulotomy is accepted as standard treatment for posterior capsule opacification (pco). although, nd:yag laser capsulotomy is a noninvasive and safe treatment it carries risk of some complications. using less total energy and performing smaller capsulotomies are effective choices to decrease complications after nd:yag capsulotomy.

PURPOSE To evaluate the development of posterior capsule opacification (PCO) in patients implanted with 5.5 mm optics, single-piece or three-piece acrylic intraocular lens (IOL) in cataract surgery prospectively. METHODS This study was carried out on 267 eyes of 249 patients implanted with three-piece, 5.5 mm optics, acrylic IOL and 252 eyes of 244 patients implanted with single-piece, 5.5 mm...

Posterior capsular opacification (PCO) is the most common complication of cataract surgery, occurring in up to 50% of cases, and a recent clinical survey suggested that the incidence is not declining in spite of improvements in surgical technique. At present PCO is treated by YAG capsulotomy, which carries a small risk of sight threatening complications such as cystoid macular oedema or retinal...

EDITORIAL It is known that pseudophakia is a very frequent condition in ophthalmology. The visual benefit obtained after a cataracts operation can diminish in time due to the progressive development of a posterior capsule opacification (PCO). Even though surgical techniques and the design and materials of intra-ocular lenses have been continuously modified, PCO continues to be the most frequent...

BACKGROUND Posterior Capsular Opacification (PCO) is one of the most common complications of cataract surgery which can result in severe visual damage. Epithelial-Mesenchymal Transition (EMT) of lens epithelium cells (LEC) is the pathological basis of PCO. Recent research showed that hypoxia acted as an inducer of EMT through a Notch1/Snail1/E-cadherin pathway. However, it remains unclear wheth...