نتایج جستجو برای: postsynaptic blocker

تعداد نتایج: 33982  

Journal: :Journal of neurophysiology 1997
K Kessey D J Mogul

The role of adenosine A2 receptors in normal synaptic transmission and tetanus-induced long-term potentiation (LTP) was tested by stimulation of the Schaffer collateral pathway and recording of the field excitatory postsynaptic potential (EPSP) in the CA1 region of rat transverse hippocampal slices. Activation of adenosine A2 receptors with the A2 agonist N6-[2-(3,5-dimethoxyphenyl)-2-(2-methyl...

Journal: :The Journal of Physiology 2021

Key points Recent studies have repeatedly demonstrated the cross-talk of heterogeneous signals between neuronal and glial circuits. Here, we investigated mechanism influence physiological interactions neurons glia in cerebellum. We found that cerebellar astrocytes, Bergmann cells, react to exogenously applied glutamate, glutamate transporter substrate (d-aspartate) synaptically released glutama...

Journal: :physiology and pharmacology 0
masoumeh kourosh arami dept. physiology, school of medical sciences, tarbiat modares university, tehran, iran saeed semnanian dept. physiology, school of medical sciences, tarbiat modares university, tehran, iran mohammad javan dept. physiology, school of medical sciences, tarbiat modares university, tehran, iran sohrab hajizadeh dept. physiology, school of medical sciences, tarbiat modares university, tehran, iran abdolrahman sarihi dept. physiology, school of medical sciences, hamedan university of medical sciences, hamedan, iran

introduction: in the present work, spontaneous postsynaptic currents were assessed to investigate the postnatal development of excitatory postsynaptic currents in locus coeruleus neurons. methods: in this study, ampa and nmda receptor-mediated spontaneous synaptic currents in the neurons of locus coeruleus were assessed using whole cell voltage-clamp recording during the first three weeks. resu...

Journal: :journal of family and reproductive health 0
saghar salehpour department of obstetric and gynaecology, ayatollah taleghani hospital, tehran, iran farah farzaneh department of obstetric and gynaecology, ayatollah taleghani hospital, tehran, iran azadeh akbari sene department of obstetric and gynaecology, ayatollah taleghani hospital, tehran, iran parisa taherzadeh boroujeni department of obstetric and gynaecology, ayatollah taleghani hospital, tehran, iran

aortic aneurysm is a rare but potentially lethal complication during pregnancy. in this article we described a 30-year-old woman with a large size descending aorta aneurysm (11 cm in length and 5.6 cm in its greatest diameter), who had two term uncomplicated pregnancies. the patient received prophylactic ß-blocker drug during her second pregnancy. both pregnancies were terminated by caesarean s...

Journal: :iranian journal of pharmaceutical research 0
s gholami f soleimani f hoseini shirazi m touhidpour m mahmoudian

mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. it has shown a better efficacy than other drugs in this group. for assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. in this study mutagenic effect of mebudipine was evaluated using ames assay that could assess the mutageni...

T Tsumoto

Brain-derived neurotrophic factor (BDNF) is known to play a role in experience-dependent plasticity of the developing visual cortex. For example, BDNF acutely enhances long-term potentiation and blocks long-term depression in the visual cortex of young rats. Such acute actions of BDNF suggested to be mediated mainly through presynaptic mechanisms. A chronic application of BDNF to the visual cor...

T Tsumoto

Brain-derived neurotrophic factor (BDNF) is known to play a role in experience-dependent plasticity of the developing visual cortex. For example, BDNF acutely enhances long-term potentiation and blocks long-term depression in the visual cortex of young rats. Such acute actions of BDNF suggested to be mediated mainly through presynaptic mechanisms. A chronic application of BDNF to the visual cor...

2015
Daniel Ulrich

Amyloid (A ) is thought to play an important role in the pathogenesis of Alzheimer’s disease. A may exert its neurotoxic effects via multiple mechanisms and in particular through degradation of excitatory synaptic transmission associated with impaired synaptic plasticity. In contrast, much less is known about A effects at inhibitory synapses. This study investigates the impact of acute A 1-42 a...

Journal: :Journal of neurophysiology 1999
K Jensen J D Lambert M S Jensen

Short-term depression of monosynaptic GABAergic inhibitory postsynaptic currents (IPSCs) evoked between pairs of cultured rat hippocampal neurons was investigated using dual whole cell patch-clamp recordings. Paired stimuli applied to the GABAergic neuron resulted in paired-pulse depression (PPD) of the second IPSC (IPSC2) at interpulse intervals from 25 to 2,000 ms. CGP 55845A, but not CGP 353...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Yu Shin Kim Jung Hoon Shin F Scott Hall David J Linden

Brief strong depolarization of cerebellar Purkinje cells produces a slow inward cation current. This current, called depolarization-induced slow current (DISC), is triggered by Ca influx in the Purkinje cell and is attenuated by a blocker of vesicular fusion. Previous work in other brain regions, such as the substantia nigra and ventral tegmental area, has shown that dopamine can be released fr...

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