Posttrasplant lymphoproliferative disorders (PTLD) represent a wide spectrum of pathologic and clinical manifestations that occur in the setting of depressed T-cell function and altered immune surveillance, such as is observed in the setting of solid organ transplantation (SOT). PTLD is a major contributor to long-term morbidity and mortality in this population and is the most common cancer obs...

Posttransplant lymphoproliferative disorder (PTLD) is a rare but life threatening disorder following both solid organ and hematopoietic stem cell transplantation. The disorder is characterized by an uncontrolled proliferation of lymphocytes, caused by medication induced diminished immune surveillance. From a pathological point of view PTLD has a broad and heterogeneous spectrum of appearance, r...

OBJECTIVES Posttransplant lymphoproliferative disorder (PTLD) causes significant morbidity and mortality, is related to Epstein-Barr virus (EBV) infection, and is more common in children than in adults. We reviewed autopsies of children who died with PTLD to compare postmortem with antemortem PTLD histology, to assess the extent of PTLD, to document associated pathology, and to identify cause o...

We investigated the characteristics of lymphocytes propagated from biopsies of the mesenteric lymph nodes, liver, and ileum of a human multivisceral allograft in order to provide functional evidence for the presence or absence of rejection and graft-versus-host disease (GVHD). The recipient was a 39-month-old girl with secretory diarrhea due to microvillus inclusion disease and end-stage liver ...