1. Exposure of neurohaemal areas to solutions of elevated K concentration (above 40 HIM) causes a maximal release of diuretic hormone in Rhodmus prolixus and Glossina austeni. 2. An involvement of Ca in hormone release is indicated by the reduction caused by low concentrations of this cation (below 2 mM) or by the presence of Mn. 3. During prolonged treatment with K-rich solutions the rate of h...

Potassium mobilizing bacteria (KMB) strains have been isolated from waste mica mines in the Giridih district of Jharkhand, India, using Alexandrov media. These isolates were evaluated for their potential to dissolve water soluble-K (muscovite and biotite). Identity was confirmed based on sequencing 16S rDNA region those showing promising dissolving capacity. Strains found be different Bacillus ...

It has recently been proposed that in rat models of genetic hypertension, supplemental dietary potassium preserves release of endothelium-derived relaxing factor independently of its capacity to either attenuate hypertension or increase plasma potassium. To test this hypothesis in Dahl salt-sensitive rats given sodium chloride (4%) for 3 weeks, we supplemented dietary potassium (2.1%) with eith...

FMRP is an RNA-binding protein that negatively regulates translation and which is lost in fragile X syndrome. In this issue of Neuron, Deng et al. (2013) demonstrate a novel translation-independent function for FMRP as a regulator of presynaptic BK channels that modulate the dynamics of neurotransmitter release.

Once the patient's cardiac state has been stabilised gastric lavage should be undertaken and calcium polystyrene sulphonate-for example, Calcium Resoriium 60 g-left in the stomach to reduce further potassium absorption. 1 g of Calcium Resonium can absorb about 1-3 mmol of potassium. Whole-gut lavage4 may also be helpful because slow-release tablets liberate potassium over three hours or longer,...

The present work comprises the formulation and evaluation delivery system of transdermal drug with a view of developing and preparing a losartan potassium releasing system utilizing natural oils as permeation enhancers for transdermal applications. Matrix systems were prepared by using polyvinyl pyrrolidine and ethyl cellulose (EC) polymers by incorporating dibutyl phthalate as plasticizer and ...

Heterozygous mutations of KCNA1, the gene encoding potassium channel Kv1.1 subunits, cause episodic ataxia type 1 (EA1), which is characterized by paroxysmal cerebellar incoordination and interictal myokymia. Some mutations are also associated with epilepsy. Although Kv1.1-containing potassium channels play important roles in neuronal excitability and neurotransmitter release, it is not known h...

Serotonin 5-HT(2A) receptors have been implicated in psychiatric illness and the psychotomimetic effects of hallucinogens. In brain slices, focal stimulation of 5-HT(2A) receptors in rat prefrontal cortex results in dramatically increased glutamate release onto layer V pyramidal neurons, as measured by an increase in "spontaneous" (nonelectrically evoked) EPSCs. This glutamate release is blocke...

Low levels of visible light directed onto slices of rat cerebral cortical tissue enhanced net potassium-induced release of the neurotransmitter gamma-aminobutyric acid (GABA) from these brain slices. At higher light intensity, net potassium-induced release was suppressed. These effects were apparently not from increased temperature. The amount of light enhancing this neurotransmitter release is...