The present study reports a microwave-assisted method for the synthesis of twelve novel tricyclic 1,4-dihydropyridine derivatives in which dimethyl-substituted cyclohexane and / or tetrahydrothiophene rings are fused to the DHP ring. The structures of the compounds were confirmed by spectral methods and elemental analysis. The potassium channel opening effects of the compounds were determined o...

Carbonate-substituted hydroxyapatite (CHA) is more osteoconductive and more resorbable than hydroxyapatite (HA), but the underlying mode of its action is unclear. We hypothesised that increased resorption of the ceramic by osteoclasts might subsequently upregulate osteoblasts by a coupling mechanism, and sought to test this in a large animal model. Defects were created in both the lateral femor...

Silicon was doped to hydroxyapatite by hydrothermal techniques for higher biocompatibility. Products contained tetra-ethyl-orthosilicate (TEOS) as a silicon source in the range of 0 to 15mass%. In order to evaluate bioactivity of silicon-doped hydroxyapatite, the samples were soaked in simulated body fluid (SBF). Silicon doped samples showed faster apatite forming ability than the undoped sampl...

The present study reports a microwave-assisted method for the synthesis of twelve novel tricyclic 1,4-dihydropyridine derivatives in which dimethyl-substituted cyclohexane and / or tetrahydrothiophene rings are fused to the DHP ring. The structures of the compounds were confirmed by spectral methods and elemental analysis. The potassium channel opening effects of the compounds were determined o...

A new series of 2-(ortho & para substituted phenoxy)1-(3-(3-chloro-4-methoxyphenyl)-5-(substituted phenyl)-4,5dihydropyrazol-1-yl)ethanone were synthesized. Ortho and para substituted phenol was refluxed with ethylchloroacetate in dry acetone in presence of anhydrous potassium carbonate to yield ethyl (ortho & para substituted phenoxy) acetate (1). The substituted ester on reaction with hydrazi...

The quality of the tissue-implant interface was evaluated using light and scanning electron microscopy with morphometric analysis. Nine dogs were implanted with 3 types of dental implants (titanium, zirconia, or alumina). A total of 24 dental implants was placed in mandibular bone previously filled with coral carbonate calcium (corail) or hydroxyapatite. The study results in breaking the concep...