A quantitative framework for the analysis of results of the Salmonella (Ames) test is presented, and the relationship between mutagenesis and carcinogenesis is examined. Color graphics are used for the Salmonella data to describe variability, and trends across multiple chemicals and test conditions. Positivity in the Salmonella test, using statistical criteria to classify results, is compared t...

measles has been a major cause of illness and death in children and vaccination against the disease is part of the who global immunization program. a suitable vaccine should create maximum immune response against the pathogen and must be safe for the user. thus, after production, vaccines must be analyzed and controlled by the producer and confirm by relevant governmental organizations. the foo...

Abstract Employees remaining silent about ethical aspects of work or organization-related issues, termed employee silence, perpetuates misconduct in today’s business setting. However, how and why it occurs is not yet well specified the ethics literature, which insufficient to manage corporate misconducts. In this research, we investigate when exploitative leadership associates with silence. We ...

One of the basic problems in the standardization of inactivated polyvalent influenza virus vaccines has been the determination of the relative potency of the individual strain components. The chicken cell agglutination test measures reliably the total hemagglutinin content of these vaccines. With immunodiffusion techniques, it is now possible to quantitate each strain component of polyvalent va...

Relative potencies for 30 compounds scheduled for carcinogenic testing in the 2-year rodent bioassays were estimated based on comparisons with a wide variety of bioassay data for benzo[a]pyrene, nicotine, cisplatin, aflatoxin B1, and cyclophosphamide. Potential for oncogenic transformation of each of the compounds was estimated from short-term bioassays. Promoting strength was assigned on the b...

lallemantia royleana (balangu) is a well known iranian medicinal plant that its seed mucilage has many applications in modern pharmacology. plant mucilage traditionally was used as a gel supplement, and natural matrix for sustained release of drugs. but it seems that these compounds are not a simple additive and also have many undiscovered pharmacological properties. in this research, the anest...

delayed-type hypersensitivity (dth) reaction measured by skin testing is an important indicator for evaluation of cellular immune response in leishmaniasis. skin testing in leishmaniasis, known as leishmanin or montenegro test, is used normally for immunoepidemiological studies and for diagnosis. in cutaneous leishmaniasis (cl), the skin test is positive during the active phase of disease and r...

A close relationship exists between calcium concentration in the central nervous system and nociceptive processing. Aminoglycoside antibiotics and magnesium interact with N- and P/Q-type voltage-operated calcium channels. In the present study we compare the antinociceptive potency of intrathecal administration of aminoglycoside antibiotics and magnesium chloride in the tail-flick test and on in...

In this work we have investigated the correlation existing between a short-term genotoxicity test (DNA repair in rat liver cells) and carcinogenicity in rodents. The work is in the framework of a line of thinking that considers as a possibility the utilization of the quantitative component of the information obtained from genotoxicity tests. In a preliminary report for 25 compounds belonging to...

Although in vitro transport/inhibition studies are commonly performed on impure drug candidates to screen for pharmacokinetic properties in early development, quantitative guidelines concerning acceptable impurity levels are lacking. The broad goal was to derive models for the effect of impurity on transport and inhibition studies and identify the maximum allowable impurity level that does not ...