In this paper a non-diagonal regulator, based on the QFT method, is synthesized for an uncertain MIMO plant whose output and control signals are subjected to hard time-domain constraints. This procedure includes the design of a non-diagonal pre-controller based on a new simple approach, followed by the sequential design of a diagonal QFT controller. We present a new formulation for the latter s...

in order to improve local therapeutic techniques for the massively burnt patients and to minimize the pain associated with dressing change, the concept of topical film was utilized to formulate a topical antimicrobial spray. the commonly used topical antimicrobial silver sulfadiazine spray was formulated as a new drug delivery system. the release of therapeutic agents in vitro from medicated sp...

Orally disintegrating tablets (ODTs) are capable of turning quickly into a liquid dosage form in contact with the saliva, thus possessing the advantages of both the solid dosage forms particularly stability and liquid dosage forms specially ease of swallowing and pre-gastric absorption of drug. The aim of this study was to prepare a novel matrix-type buccal fast disintegrating ibuprofen tablet ...

We present a new model for finding the optimal placement of electric vehicle charging stations across multi-period time frame so as to maximise adoption. Via use advanced discrete choice models and user classes, this work allows granular modelling attributes their preferences in regard station characteristics. Instead embedding an analytical probability formulation, we adopt simulation approach...

Clay minerals are still widely used in pharmaceutical products for human health and cosmetic purposes. Pre-formulation studies were conducted to identify solid-state properties of pink clay, a sample from Diamantina, Brazil. Among the solid be analyzed, we have selected type identification, iron phases, crystallinity, powder flow characteristics, thermal behavior, non-isothermal phase transitio...

In this paper, an enhanced solid finite element formulation for rotor dynamics analysis is presented. The kinematics first defined with a Total Lagrangian in order to account possible centrifugal stiffening effect and its associated pre-stress deformation. novelty of the three-dimensional proposed study then correctly consider inertia due small rotational deformation occurring around pre-stress...

A simple and sensitive assay method for a pharmacokinetic study of Menaquinone-4 in dogs was established using HPLC with fluorescence detection following extraction with organic solvent. The quantification limit of this method was 1 ng/ml of plasma. A new oily solution formulation of Menaquinone-4 was administered orally to nonfasted dogs at doses of 0.4, 4 and 40 mg/kg. The plasma concentratio...