Multispectral widefield optical imaging has the potential to improve early detection of oral cancer. The appropriate selection of illumination and collection conditions is required to maximize diagnostic ability. The goals of this study were to (i) evaluate image contrast between oral cancer∕precancer and non-neoplastic mucosa for a variety of imaging modalities and illumination∕collection cond...

Precancerous skin lesions are associated with high probability of malignant transformation to squamous cell carcinoma. Early detection and management necessary improve prognosis outcomes. Literatures showed that topical photodynamic therapy (PDT) is a promising treatment method which can be successfully applied in several conditions dermatology. This study aims review the efficacy PDT for vario...

Adenomatous hyperplasia (AH) of the liver is considered a precancerous lesion because hepatocellular carcinoma (HCC) has been found in nodules of AH at histologic examination. Contrast material-enhanced ultrasound (US) with intraarterial infusion of carbon dioxide microbubbles was performed in four patients with HCC in AH lesions. In all four patients, a "hyperechoic focus in an area of hypoech...

Chromosomal integration of high-risk human papillomavirus (HR-HPV) genomes is believed to represent a significant event in the pathogenesis of cervical cancer associated with progression from preneoplastic lesions to invasive carcinomas. This hypothesis is based on experimental data suggesting that integration-dependent disruption of HR-HPV E2 gene functions is important to achieve neoplastic t...

Chronic atrophic gastritis and intestinal metaplasia related to Helicobacter pylori infection, are major risk factors for gastric adenocarcinoma. Eradication of H pylori and endoscopy surveillance of precancerous lesions may reduce the risk and/or lead to early detection of gastric cancer improving survival. In this study, the progression of precancerous lesions after H pylori treatment was eva...

Optical spectroscopy can provide useful diagnostic information about the morphological and biochemical changes related to the progression of precancer in epithelial tissue. As precancerous lesions develop, the optical properties of both the superficial epithelium and underlying stroma are altered; measuring spectral data as a function of depth has the potential to improve diagnostic performance...

introduction calcifying odontogenic cyst (coc) is an uncommon odontogenic lesion, classified in two variants: the cystic variant and neoplastic (solid) variant. case presentation this case report presents multiple coc, which involved the maxillary bone and sinus in a 30-year-old man. several of these lesions were cystic, while the others were neoplastic in type, and the lesions were removed sur...

Precancerous conditions in the gallbladder are still a matter of interest of numerous investigators, but reliable and definite attitude is not jet available. Particularly, many regenerative/reparative changes during inflammation and cholelithiasis in the gallbladder cannot be classified with certainty as lesions which precede malignant alteration. However, it is considered that metaplastic-dysp...