OBJECTIVES To identify if preclinical syndromes for Alzheimer's disease, vascular dementia, and Parkinson's disease and related dementias exist. Identification of dementia at early or even preclinical stages has important implications for treatment. METHODS A community dwelling sample of 647 subjects aged 75 and over at recruitment were followed up for a mean period of 3.19 years (range 2.61 ...

Stroke is one of the leading causes of death worldwide and the biggest reason for long-term disability. Basic research has formed the modern understanding of stroke pathophysiology, and has revealed important molecular, cellular and systemic mechanisms. However, despite decades of research, most translational stroke trials that aim to introduce basic research findings into clinical treatment st...

Gold quantum clusters are therapeutic in preclinical models of Friedreich ataxia.

Ultrasound imaging of the heart is a non-invasive method widely used for different applications. One of them is to measure the blood volume in the left ventricle at different stages of the heart cycle. This demands a proper segmentation of the left ventricle and a (semi-) automated method would decrease intra-variability as well as workload. This paper presents a semi-automated segmentation met...

How do groups resist the apparently all encompassing discourse of management? Rejecting current theories of resistance as ‘re-appropriation’ or ‘micro-politics’, we argue that resistance may be thought about as hegemonic struggle which are undertaken by social movements. We identify four major resistance movements that engage with management: unions, organizational misbehaviour, civic movements...

Current standard clinical SPECT techniques provide a resolution of at best 1 cm and sensitivity in the order of 10. Performance is largely determined by the collimator. Basic geometry couples resolution and sensitivity; the problem of high-resolution imaging is a formidable one because, to image at constant Signal-to-Noise, resolution improvements must be supported by simultaneous sensitivity i...

The concept of probiotic has been around for more than century. Their impact on human nutrition is still an emerging science, and knowledge of human intestinal micro flora is still growing. To determine the positive effect of probiotic strain, necessary tools are required to monitor the specific strain in the intestines. The addition of molecular methods to conventional microbiological methods ...