BACKGROUND A trial of corticosteroids has been recommended for all patients with chronic obstructive pulmonary disease (COPD), with the subsequent "response" determining the treatment selected. This approach assumes that patients can be reliably divided into responder and non-responder groups. We have assessed whether such a separation is statistically valid, which factors influence the change ...

Introduction: Sudden sensorineural hearing loss (SSNHL) is a true emergency that must be diagnosed and treated immediately. The purpose of this study is to compare the efficacy of treatment with intratympanic dexamethasone plus oral prednisolone daily or every other day with that of treatment with oral prednisolone alone. Materials and Methods: Sixty-three patients with SSNHL that had been p...

Kafirin microparticles have potential as colon-targeted delivery systems because of their ability to protect encapsulated material from digestive processes of the upper gastrointestinal tract (GIT). The aim was to optimize prednisolone loading into kafirin microparticles, and investigate their potential as an oral delivery system. Response surface methodology (RSM) was used to predict the optim...

Anti-inflammatory potency of 5-hydroxypyrimidine derivatives SNK-411 (2-isobutyl-4,6-dimethyl-5-hydroxypirimidine) and SNK-578 (hydrochloride 2-isobutyl-4,6-dimethyl-5-hydroxypirimidine) was evaluated on the model complete Freund`s adjuvant (CFA)-induced exudative inflammation in experiment 60 outbreed male rats weighing 180–200 g comparison with prednisolone. Prednisolone, were injected twice:...

central serous chorioretinopathy (cscr) is an ocular disease which fluid is collected under retina and leads to retinal detachment and blurred vision. risk factors for development of central serous chorioretinopathy are included: alcohol use, uncontrolled hypertension, pregnancy, type a personalityand different ways of corticosteroid use. we want to present central serous chorioretinopathy in a...

introduction:  asthma exacerbation is common in children. treatment with oral corticosteroids (ocs) and inhaled corticosteroids are suggested for asthma exacerbation. it is shown that inhaled corticosteroids has similar outcome in reducing asthma symptoms compared to ocs. but few studies have evaluated the pulmonary function changes in these two treatments. in this study, we evaluated the chang...

Peripheral blood eosinophil counts (EOS) are undetectable in 40% blood samples sent for routine haematology at Papworth Hospital during the first 3 months after heart transplantation (HTx). Increases in EOS usually precede the development of allograft rejection by a median of 4 days. We compared the effects of cyclosporin (dose and total blood concentration), prednisolone (dose and both total a...

OBJECTIVE To study whether prednisolone reduces sequelae in Bell's palsy. DESIGN Prospective, randomized, double-blind, placebo-controlled, multicenter trial with 12 months of follow-up. SETTING Seventeen referral centers. PATIENTS In all, 829 patients aged 18 to 75 years. INTERVENTIONS Randomization within 72 hours in a factorial fashion to placebo plus placebo (n = 206); prednisolone,...

BACKGROUND There is no study on the long-term use of prednisolone in post-stroke complex regional pain syndrome-1 (CRPS1). OBJECTIVE To evaluate the efficacy and safety of long-term low dose prednisolone in post-stroke CRPS-I. STUDY DESIGN Open-labeled randomized controlled trial. SETTING Tertiary care teaching institute. METHODS Seventy-seven out of 396 (19.4%) patients with stroke had...

Objective—To determine the eVect of adjunctive prednisolone on morbidity, pericardial fluid resolution, and mortality in HIV seropositive patients with eVusive tuberculous pericarditis. Design—Double blind randomised placebo controlled trial. Setting—Two medical school aYliated referral hospitals in Harare, Zimbabwe. Patients—58 HIV seropositive patients aged 18–55 years with tuberculous perica...