osteopenia of prematurity (oop) is a preventable disease. improved survival of premature newborns is associated with an increased incidence of oop. the purpose of this study was to compare the prophylactic effects of two low doses of vitamin d (200 and 400 iu/day) on the clinical, biochemical and radiological indices of the rickets of prematurity. in a randomized clinical trial, 60 preterm newb...

purpose: to study the effects of adding intravitreal bevacizumab (avastin) to conventional laser treatment on regression of retinal neovascularization in threshold rop. methods: intravitreal injection of bevacizumab (1.25 mg) in one eye of each of three newborns with threshold rop was performed in addition to laser treatment. the other eye of each patient was treated with laser alone. changes i...

The purpose of this article is to explore the psychosocial antecedents of prematurity. Emphasis is on conceptual areas and supporting literature for (a) the contexts in which prematurity occurs and the diversity of women's experiences; (b) a lifecourse approach to prematurity that highlights allostatic load and the accumulation of trauma and loss in possible prematurity pathways; and (c) divers...

OBJECTIVE To evaluate the prevalence of retinopathy of prematurity and the risk factors affecting very low birth weight infants at a neonatal intensive care unit. METHODS A cross-sectional study investigating all newborn infants with birth weights < or = 1,500 g and/or gestational ages < or = 32 weeks, admitted to the Neonatal ICU at the Hospital de Clínicas de Porto Alegre, from October 2002...

PURPOSE To evaluate the role of mitogen-activated protein kinase kinase (MKK) signaling in a mouse model of oxygen-induced retinopathy (OIR) that mimics retinopathy of prematurity (ROP). METHODS Postnatal day 7 mice were exposed to elevated oxygen for 5 days to induce retinopathy. Anthrax lethal toxin (LeTx), an MKK inhibitor, was injected into the vitreous after restoration to normoxia, and ...

Retinopathy (RP) is a microvascular complication induced by diabetes and hypertension. Its onset and progression are associated with chronic hyperglycemia and dysregulated arterial hypertension. In microvascular abnormality, it is observed increased oxidative stress and elevated inflammatory cytokines in the eyes. Diabetic retinopathy is triggered by hyperglycemia of diabetes, however, while in...