Interstitial telomeric sequences (ITSs), telomere-like repeats at intrachromosomal sites, are common in mammals and consist of tandem repeats of the canonical telomeric repeat, TTAGGG, or a repeat similar to this. We report that the ITS in human chromosome region 22q11.2 is, in the sequenced genome database, 101 tandem repeats of the sequence TTAGGGAGG. Using the primed in situ labeling (PRINS)...

Locus equations offer promise for an understanding of at least some aspects of perceptual invariance in speech, but they were discovered almost fortuitously. With the present availability of powerful machine learning algorithms, ‘ignorance-based’ automatic discovery procedures are starting to supplant ‘knowledge-based’ scientific inquiry. Prin-

The Prins reaction was investigated using BF₃.OEt₂ as a Lewis acid. It has been recently demonstrated, that if BF₃.OEt₂ is used in stoichiometric amounts then these reactions generate fluorinated products where the BF₃.OEt₂ contributes fluoride ion to quench the intermediate carbocations. In this study oxa- and aza-Prins reactions for the synthesis of 4-fluoro-pyrans and -piperidines were inves...

A novel Lewis acid catalyzed Prins/pinacol cascade process has been developed for the synthesis of 7-substituted-8-oxaspiro[4.5]decan-1-ones in good yields with excellent selectivity. This is the first example of the synthesis of oxaspirocycles from aldehydes and 1-(4-hydroxybut-1-en-2-yl)cyclobutanol through a cascade of Prins/pinacol rearrangement. This method is applicable to a wide range of...

Tetrahydropyrans are common motifs in natural products and have now been constructed with high stereocontrol through a three-component allylboration-Prins reaction sequence. This methodology has been applied to a concise (13 steps) and efficient (14 % overall yield) synthesis of the macrolide (-)-clavosolide A. The synthesis also features an early stage glycosidation reaction to introduce the x...

Supramolecular assembly 1 catalyzes a bimolecular aza-Prins cyclization featuring an unexpected transannular 1,5-hydride transfer. This reaction pathway, which is promoted by constrictive binding within the supramolecular cavity of 1, is kinetically disfavored in the absence of 1, as evidenced by the orthogonal reactivity observed in bulk solution. Mechanistic investigation through kinetic anal...

In minority games, players in a group must decide at each round which of two available options to choose, knowing that only subjects who picked the minority option obtain a positive reward. Previous experiments on the minority and similar congestion games have shown that players interacting repeatedly are remarkably able to coordinate e ciently, despite not conforming to Nash equilibrium behavi...

Abstra t. The spa e requirement of Cro hemore's repetitions algorithm is generally estimated to be about 20MN bytes of memory, where N is the length of the input string and M the number of bytes required to store the integer N . The same algorithm an also be used in other ontexts, for instan e to ompute the suÆx tree of the input string in O(N logN) time for the purpose of data ompression. In s...