Vitiligo, manifested by skin hypopigmentation, is an autoimmune disorder of the due to destruction melanocytes. Nivolumab, which a programmed cell death–1 receptor inhibitor, well-known therapy for melanoma. Nivolumab-induced vitiligo has been described in literature, explained non-cancerous This considered favorable response, correlated stronger immune response against tumor cells. The average...

in many models of programmed cell death, the mitochondrial protein aif translocates to the nucleus, where it induces the chromatin condensation and dna degradation. however, today it is well established that this flavoprotein is bifunctional. in addition to its lethal function in the nucleus of dying cells, aif plays a vital bioenergetic role in healthy ones by regulating mainly the activity of...