Background: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system and cytokines may play a role in the development of MS lesions. Objective: To determine levels of different cytokines in patients with relapsing-remitting MS (RR-MS) compared to healthy controls. Methods: Profiles of pro-inflammatory, Th1-, Th2-, and Th17-related cytokines were compared by quantitative ...

The worldwide incidence, morbidity and mortality of asthma are increasing dramatically. It is one of the most common disorders encountered in clinical medicine in both children and adults. It affects approximately 5% of the adult population in the western world and its reported incidence is increasing vigorously in many developed nations. A network of a novel mediator known as ‘pleiotropic cyto...

patients with allergic rhinitis (ar) show increased production of the th2-related cytokines. almost always, intranasal corticosteroid (inc) and antihistamine are used as routine therapy of ar. this study was performed to determine the in vitro secretion of cytokines profiles of pbmcs in patients with ar sensitive to chenopodium album (ch.a) pollens before and after treatment with inc (fluticaso...

brain death is associated with increased inflammatory cytokines levels and poor graft quality to transplant. we aimed to evaluate the impact of ascorbic acid (aa) on the inflammatory status of brain-dead donors (bdds). forty bdds were randomly divided into two groups. donor treatment (n=20) consisted of 100 mg/kg aa infusion 6 hours before donor operation and subsequent infusion of 100 mg/kg/p6...

this study evaluated the effects of mesobuthus eupeus (me) scorpion venom on inflammatory response following injection. additionally, the present study examined whether immunotherapy at specific time intervals would be effective on inflammatory response after me venom inoculation. animals were divided randomly into four groups: the first group received ld50 of venom and the second and third gro...

stress-related mucosal damage (srmd) is a significant cause of morbidity and mortality in critically ill patients due to the gastrointestinal blood loss. prophylaxis of srmd with proton pump inhibitors or histamine-2 blockers has gained widespread use in intensive care units. both demonstrated to be effective in reducing clinically significant bleedings, while ppis has shown to exert some anti ...

background t-helper (th) lymphocyte cytokine production may be important in the immune pathogenesis of hepatitis c virus (hcv) infections. th1 cytokines such as; interleukin- 2 (il-2), and interferon gamma (ifn-gamma) are necessary for host antiviral immune responses, while th2 cytokines (il-4, il-10) can inhibit the development of these effector mechanisms. objectives the aim of the present st...

gamma irradiation is routinely used for suppression of lymphocyte function in transfusion and transplantation procedures. in recent years, some investigators focused on the effects of ionizing radiation on special aspects of lymphocyte function and considered the possibility of its clinical application for treatment of some immunological disorders. in this study, we evaluated the effects of fiv...