OBJECTIVE To determine whether haloperidol alone results in swifter and safer tranquillisation and sedation than haloperidol plus promethazine. DESIGN Pragmatic randomised open trial (January-July 2004). SETTING Psychiatric emergency room, Rio de Janeiro, Brazil. PARTICIPANTS 316 patients who needed urgent intramuscular sedation because of agitation, dangerous behaviour, or both. INTERV...

The effects of an oral administration of carbon tetrachloride on various liver microsomal and supernatant components were studied 1hr. and 2hr. after dosing. The modifications of such early changes resulting from a concomitant administration of promethazine together with the carbon tetrachloride were also investigated. The microsomal components studied were: cytochromes P-450 and b(5); inorgani...

BACKGROUND The aim was to compare the efficacy and safety of a combination of intramuscular ketorolac and chlorpromazine for the treatment of acute exacerbations of chronic pain with the more commonly used regimen of intramuscular meperidine and promethazine. METHODS Use-effective case series were drawn from a real-life, rural emergency department practice, in which 200 consecutive patients c...

UNLABELLED Nuclear medicine technology assumes responsibility for examination-specific patient preparation procedures. This requires a clear understanding of the possible effects of medications on the outcome of examinations. There is evidence that common over-the-counter drugs, histamine 1 (H1) and histamine 2 (H2) receptor blockers and proton pump inhibitors, may directly or indirectly affect...

the complexation reactions between cu2+, pd2+ and ni2+ metal ions with promethazine (pm) in water or dmf were studied by the spectrophotometric methods at [(15, 25,35 and 45±0.1) °c]. the complexation process was optimized in terms of ph, temperature and contact time. the stoichiometry of the complex was found to be 1:1 (metal ion/ligand). the formation constants of the resulting complexes were...

The Cover Feature represents the concept of feeding pharmaceuticals into a hopper placed on top NMR magnet looking at 35Cl nuclear isotope, and molecular conformations for promethazine, duloxetine trifluoperazine, as studied in paper, coming out bottom, set snowy wintry background. More information can be found Research Article by Leslie P. Hughes, Steven Brown co-workers.