BACKGROUND Prophylactic mastectomy is performed to decrease the risk of breast cancer in women at high risk for the disease. The benefit of sentinel lymph node biopsy (SLNB) at the time of prophylactic mastectomy is controversial, and we performed a meta-analysis of the reported data to assess that benefit. METHODS We searched MEDLINE, EMBASE and the Cochrane Library databases from January 19...

Resveratrol (RSV), a polyphenolic compound and naturally occurring phytoalexin, has been reported to exert cardio-protective effects in several animal studies. However, the outcome of initial clinical trials with RSV was less effective compared to pre-clinical studies. Therefore, RSV treatment protocols need to be optimized. In this study we evaluated prophylactic versus therapeutic effect of r...

BACKGROUND The SMART trial is a UK-based, multicentre RCT comparing prophylactic radiotherapy and symptom-based (deferred) radiotherapy in 203 patients with Malignant Pleural Mesothelioma who had undergone large bore pleural interventions. Using costs and quality of life data collected alongside the clinical trial, we will estimate the cost-effectiveness of prophylactic radiotherapy compared to...

Temporal Trends in and Factors Associated With Contralateral ProphylacticMastectomy AmongUSMenWith Breast Cancer Previous studies have reportedmarked increases in the rates of contralateral prophylactic mastectomy (CPM) among US womenwho receivedadiagnosis of unilateral invasivebreastcancer, and this increase isparticularlyevidentamongyounger women.1 Rates of CPM amongwomen vary depending on th...

Although prophylactic mastectomy significantly reduces the incidence and recurrence of breast cancer, little is known about women's information needs before the procedure. We surveyed 967 women, from 6 healthcare systems, with bilateral or contralateral prophylactic mastectomy performed between 1979 and 1999. There were 2 open-ended questions: "What one thing do you wish you had known before yo...

AIMS To investigate the incidence of acute and cicatricial retinopathy of prematurity (ROP) in a cohort of premature neonates entered into a randomised, multicentre trial of prophylactic exogenous surfactant for respiratory distress syndrome (RDS) compared with controls receiving surfactant only if severe RDS developed. METHODS The incidence of acute and cicatricial ROP was assessed in 304 ne...

OBJECTIVE Trauma patients are at high risk for life-threatening venous thromboembolic (VTE) events. We examined the relationship between prophylactic inferior vena cava (IVC) filter use, mortality, and VTE. SUMMARY BACKGROUND DATA The prevalence of prophylactic placement of IVC filters has increased among trauma patients. However, there exists little data on the overall efficacy of prophylact...

Forty-nine out of 60 persons who committed suicide had been under the care of 71 physicians within 6 months or less before committing suicide. Over two thirds of the patients had histories of suicide attempts or threats. These histories were known to only two fifths of the physicians responsible for their care, despite the information being readily available from other sources. There was substa...