In the generation of flavivirus particles, an internal cleavage of the envelope glycoprotein prM by furin is required for the acquisition of infectivity. Unlike cleavage of the prM of other flaviviruses, cleavage of dengue virus prM is incomplete in many cell lines; the partial cleavage reflects the influence of residues at furin nonconsensus positions of the pr-M junction, as flaviviruses shar...

After-sales services bundled to products, respectively integrated Product-Service-Systems, have gained financial and strategic importance in manufacturing companies. Not considered as core competence in the beginning, the structures for delivering ASFS have grown over years, becoming more complex and less transparent. As industry still lacks tools and methods for ASFS network design and plannin...

Pradimicin (PRM) induces apoptosis in mammalian cells which had been incubated with 1-deoxymannojirimycin (DMJ). Flow cytometric analysis revealed that PRM preferentially induced apoptosis to the cells of the G1 phase. Two possible mediators in this apoptotic cascade were identified. Exposure of DMJ-treated cells to PRM resulted in a rapid (approximately 5 seconds) and slow (approximately 30 mi...

The key factor of the current e-business is collaboration. It is especially crucial to Partner Relationship Management (PRM) that manages the collaborative relationships between a company and its partners and controls available conflicts. Therefore, business processes supporting the dynamic nature are to be implemented on information systems. To achieve it, collaborative processes that respond ...

Probabilistic roadmap (PRM) planners [5, 16] solve apparently difficult motion planning problems where the robot's configuration space C has dimensionality six or more, and the geometry of the robot and the obstacles is described by hundreds of thousands of triangles. While an algebraic planner would be overwhelmed by the high cost of computing an exact representation of the free space F , defi...

Flaviviruses are assembled to bud into the lumen of the endoplasmic reticulum (ER) and are secreted through the vesicle transport pathway. Virus envelope proteins play important roles in this process. In this study, the effect of mutations in the envelope proteins of tick-borne encephalitis (TBE) virus on secretion of virus-like particles (VLPs), using a recombinant plasmid expression system wa...

We propose the use of quasi-random sampling techniques for path planning in high-dimensional conng-uration spaces. Following similar trends from related numerical computation elds, we show several advantages ooered by these techniques in comparison to random sampling. Our ideas are evaluated in the context of the probabilistic roadmap (PRM) framework. Two quasi-random variants of PRM-based plan...

Pradimicin A (PRM-A), an antifungal nonpeptidic benzonaphtacenequinone antibiotic, is a low-molecular-weight (molecular weight, 838) carbohydrate binding agent (CBA) endowed with a selective inhibitory activity against human immunodeficiency virus (HIV). It invariably inhibits representative virus strains of a variety of HIV-1 clades with X4 and R5 tropisms at nontoxic concentrations. Time-of-a...