BACKGROUND The latency-associated antigen Rv2659c is a starvation-related protein of Mycobacterium tuberculosis (M. tuberculosis). It has potential use in tuberculosis (TB) control, but its immunological characteristics in Chinese populations are unclear. METHODS In this study, immunological characteristics and potential diagnostic use of recombinant Rv2659c protein were assessed. Interferon-...

Tuberculosis (TB) is a disease with the second number of cases in Indonesia. The therapy process carried out by utilizing one waste materials, namely squid ink bags, which are predicted to have active compounds. In TB cycle, enzyme FabH catalyzed as mediator lipid synthesis. Inhibition became main target through role has potential bactery inhibitor. purpose this study was analyze an alternative...

Tuberculosis (TB) remains the leading cause of death due to a single pathogen, accounting for 1.5 million deaths annually on global level. Mycobacterium tuberculosis, causative agent TB, is persistently exposed stresses such as reactive oxygen species (ROS), nitrogen (RNS), acidic conditions, starvation, and hypoxic all contributing toward inhibiting bacterial proliferation survival. Iron–sulfu...

More humans have died of tuberculosis (TB) than any other infectious disease and millions still die each year. Experts advocate for blood-based, serum protein biomarkers to help diagnose TB, which afflicts people in high-burden countries. However, the biomarker pipeline is small. Here, we used Diversity Outbred (DO) mouse population address this gap, identifying five candidates. One biomarker, ...

BACKGROUND Effective treatment and monitoring of tuberculosis (TB) requires biomarkers that can be easily evaluated in blood samples. The aim of this study was to analyze the serum proteome of patients with TB and to identify protein biomarkers for TB. METHODS Serum samples from 26 TB patients and 31 controls were analyzed by using nano-flow ultra-performance liquid chromatography coupled to ...

Pulmonary tuberculosis (TB) is a chronic respiratory infectious disease. Certain microRNAs (miRNAs or miRs) are reported to be involved in regulating TB progression. The present study aimed evaluate the diagnostic potential of miR?125b pulmonary TB. expression levels and Raf1 proto?oncogene serine/threonine protein kinase (RAF1) were analyzed via reverse transcription?quantitative (RT?q)PCR pat...

BACKGROUND Protein may have both beneficial and detrimental effects on bone health depending on a variety of factors, including protein source. OBJECTIVE The aim was to conduct a systematic review and meta-analysis evaluating the effects of animal versus plant protein intake on bone mineral density (BMD), bone mineral content (BMC) and select bone biomarkers in healthy adults. METHODS Searc...

background according to several studies, diabetes mellitus has been recognized as one of the main risk factors for pulmonary tuberculosis (ptb). objectives the main purpose of this study was to determine the frequency of smear-positive pulmonary tuberculosis (tb) in patients with diabetes. materials and methods this cross-sectional study was conducted from april 2010 to december 2011 in ali asg...

Pleural tuberculosis (TB), together with lymphatic TB, constitutes more than half of all extrapulmonary cases. Pleural effusions (PEs) in TB are representative of lymphocytic PEs which are dominated by T cells. However, the mechanism underlying T lymphocytes homing and accumulation in PEs is still incompletely understood. Here we performed a comparative analysis of cytokine abundance in PEs fro...

BACKGROUND Differential diagnosis between pulmonary tuberculosis (TB) and bacterial community-acquired pneumonia (CAP) is often challenging. The neutrophil-lymphocyte count ratio (NLR), a convenient marker of inflammation, has been demonstrated to be a useful biomarker for predicting bacteremia. We investigated the usefulness of the NLR for discriminating pulmonary TB from bacterial CAP in an i...