An adolescent female with sickle cell trait presented with acute neurologic deterioration during treatment for pseudotumor cerebri. Cranial computed tomography, initially normal, subsequently revealed multiple hemorrhagic infarctions. Suspected superior sagittal sinus thrombosis was confirmed by cerebral angiography. Superior sagittal sinus thrombosis associated with sickle cell trait is exceed...

Accepted, September 15, 2003. OBJECTIVE: The history, diagnosis, and therapy of idiopathic intracranial hypertension (IIH) (pseudotumor cerebri) are reviewed. Theories of pathogenesis are considered, the clinical presentation is described, and potential diagnostic and therapeutic challenges are explored. METHODS: An extensive literature review of IIH and related conditions (secondary pseudotumo...

Oral isotretinoin is a well-known, effective medication used in the treatment of severe cystic acne. While efficacious, potential side effects are often discussed and may cause concern for patients. Although most this mild, other more concerning adverse have been reported. Of note, has to affect central nervous system (CNS), causing headaches, pseudotumor cerebri, fetal CNS malformations. In co...

A 29-year-old woman with a 4-year history of multifocal fibrosclerosis showed unique neurologic complications. Episcleritis, orbital pseudotumor, and eosinophilic phlegmon preceded intracranial inflammatory pachymeningitis. The pachymeningitis was associated with disturbance of the visual field, incomplete Gerstmann's syndrome, and pseudotumor cerebri. T2-weighted magnetic resonance images reve...

First proposed by De Wecker! in 1872 as a treatment for neuroretinitis, optic nerve sheath decompression (or fenestration) is an operation that has caused much controversy. This surgical therapy was not seriously considered until Davidson" and Smith, Hoyt, and Newton" reintroduced it in 1969 as an alternative therapy for chronic disk edema. Over the next 19 years, however, only about 60 cases o...