Submit Manuscript | http://medcraveonline.com Abbreviations: IVB: Intravitreal Bevacizumab; CNV: Choroidal Neovascularization; AS: Angioid Streaks; PXE: Pseudoxanthoma Elasticum; FFA: Fundus Fluorescein Angiography; OCT: Optical Coherence Tomography; RPE: Retinal Pigment Epithelium; PDT: Photo Dynamic Therapy; VEGF: Vascular Endothelial Growth Factor; AMD: Age-related Macular Degeneration; BCVA...

INTRODUCTION We describe the long-term effectiveness and tolerability of intravitreal vascular endothelial growth factor inhibitor ranibizumab in a patient with pseudoxanthoma elasticum with bilateral macular choroidal neovascularization secondary to angioid streaks. CASE PRESENTATION A 54-year-old Caucasian man with history of heart disease presented with visual loss in his right eye. An exa...

<p class="abstract">Pseudoxanthoma elasticum (PXE) is a hereditary systemic connective tissue disease affecting mainly the skin, retina and cardiovascular system. Pathologically, it characterized by mineralization fragmentation of elastic fibers (so-called "elastorhexia"). PXE associated with mutations in ABCC6 (ATP binding cassette subtype C number 6) gene. Women are affected more than m...