BACKGROUND Psoriasis may significantly impair sexual function. Depression and organic factors appear to play a key role in this relation. However, beyond genital psoriasis, the importance of the disease's distribution patterns has not been considered. OBJECTIVES To research sexual function in psoriasis patients and investigate the roles of anxiety, depression and psoriasis' distribution patte...

Psoriasis is an autoimmune and recurrent chronic inflammatory skin disease. About 1-3% of the world wide populations are affected. The characteristic features are hyperprolifration of keratinocytes leading to redness, thickening and scaling of epidermis followed with itching and appearance of the lesions which in most cases bother the patients medically and psychologically. Psoriasis is symptom...

Introduction Accumulating evidence indicates that psoriasis is associated with obesity and metabolic syndrome. Psoriasis and obesity share similar inflammatory mediators, and obesity may potentiate some inflammatory cytokines seen in psoriasis. Body fat distribution, particularly visceral adipose tissue (VAT), is an important factor in metabolic syndrome and atherosclerotic diseases. An associa...

BACKGROUND The Psoriasis Area and Severity Index (PASI) is the score of choice to grade psoriasis severity and detect clinical changes. Due to low resolution based on the calculation of the score by fixed area classes, PASI scores <10 have little value. METHODS At 756 patient examinations, psoriasis activity was measured with both PASI and PrecisePASI. RESULTS PrecisePASI has a linear incre...

Psoriasis is a chronic inflammatory skin disease characterized by alterations in cytokines produced by both Th1 and Th17 pathways. The aim of this study was to evaluate serum levels of pivotal cytokines and correlate them with clinical parameters. Serum samples from 53 psoriasis patients and 35 healthy volunteers, matched by the proportion of sex and age ratios, were collected for ELISA cytokin...

BSA: body surface area HLA: human leukocyte antigen IL: interleukin PGA: physician global assessment Th: T helper INTRODUCTION Guttate psoriasis is an acute, eruptive form of psoriasis characterized by small, scaly papules and plaques. The exact immunopathogenesis of guttate psoriasis is unclear. However, this subtype of psoriasis shares several features with plaque psoriasis, including an asso...

Background: Quality of life (QoL) assessment is becoming crucial in clinical trials, particularly with psoriasis. Objectives: The aim of this study was to evaluate QoL by the Moroccan version of the DLQI (Dermatology Life Quality Index) among psoriatic patients compared to vitiligo. Methods: This is a prospective study of patients aged 18 or older, who consulted at the dermatology clinic for ps...

Psoriasis is a chronic inflammatory skin condition which affects 2-3% of population around the world. Psoriasis Area and Severity Index (PASI) is a gold standard to assess psoriasis severity as well as the treatment efficacy. Although a gold standard, PASI is rarely used because it is tedious and complex. In practice, PASI score is determined subjectively by dermatologists, therefore inter and ...

Psoriasis is a disorder caused by genetic and immunological factors. Leptin, a peptide hormone secreted predominantly from adipose tissue, regulates energy intake and expenditure, as well as the T-helper response. There have been conflicting reports regarding serum levels of leptin and adiponectin in patients with psoriasis. In the present study, we measured serum levels of leptin and adiponect...

BACKGROUND Psoriatic arthritis is an inflammatory arthritis which is associated with psoriasis. There is no general agreement in the literature regarding the epidemiology of psoriatic arthritis. In this study, we evaluated the prevalence of psoriatic arthritis in a relatively large number of psoriatic patients. METHODS Three hundred and twenty patients with psoriasis were evaluated in a cross...