OBJECTIVE To investigate whether biochemical insoluble tau with 4 (4R) and/or 3 (3R) microtubule-binding repeats accumulate in white as well as gray matter in progressive supranuclear palsy (PSP), a neurodegenerative tauopathy. METHODS To assess tau pathology in PSP white matter, we combined Western blot (WB) and immunohistochemical methods to analyze 23 autopsy-confirmed PSP brains. RESULT...

OBJECTIVE The objective of this study was to compare the technical errors of intraoral radiographs exposed on film v photostimulable phosphor (PSP) plates. METHODS The intraoral radiographic images exposed on phantoms from preclinical practical exams of dental and dental hygiene students were used. Each exam consisted of 10 designated periapical and bitewing views. A total of 107 film sets an...

INTRODUCTION Patients with rheumatoid arthritis (RA) who are treated with adalimumab (ADA) are offered a proprietary patient support program (PSP, AbbVie Care®). The main objective of this study was to examine the effectiveness of ADA on RA treatment course over time in the context of PSP utilization. METHODS PASSION was a 78-week post-marketing observational study of RA patients with an insu...

Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by vertical supranuclear palsy and parkinsonian symptoms. The neuropsychiatric symptoms of PSP include anhedonia, depressed mood and cognitive impairment. Patients with PSP have an increased risk for developing depressive disorders within the next year. However, it is rare to find that major depressive disorder wa...

The clinical diagnosis of progressive supranuclear palsy (PSP) relies on the identification of characteristic signs and symptoms. A proportion of pathologically diagnosed cases do not develop these classic features, prove difficult to diagnose during life and are considered as atypical PSP. The aim of this study was to examine the apparent clinical dichotomy between typical and atypical PSP, an...

INTRODUCTION The main long-term therapeutic goals of schizophrenia should go beyond the symptoms and include the improvement of patients' psychosocial functioning and quality of life. The aim of this study was to validate the Personal and Social Performance (PSP) scale in Spanish outpatients with schizophrenia. MATERIALS AND METHODS Naturalistic, 6-month follow-up, multicentre study. 244 pati...

The Personal Software Process is a process improvement methodology aiming at individual software engineers. It claims to improve software quality (in particular defect content), effort estimation capability, and process adaptation and improvement capabilities. We have tested some of these claims in a controlled experiment comparing the performance of participants who had just previously receive...

In this paper, we present: 1) design of a single-rail energy-efficient 64-b Han–Carlson ALU, operating at 482 ps in 1.5 V, 0.18m bulk CMOS; 2) direct port of this ALU to 0.18m partially depleted SOI process; 3) SOI-optimal redesign of the ALU using a novel deep-stack quaternary-tree architecture; 4) margining for max-delay pushout due to reverse body bias in SOI designs; and 5) performance scal...