نتایج جستجو برای: pth1r

تعداد نتایج: 132  

Journal: :Journal of the American Society of Nephrology : JASN 2005
Arantxa Ortega David Rámila Adriana Izquierdo Laura González Antonio Barat Rosa Gazapo Ricardo J Bosch Pedro Esbrit

Parathyroid hormone-related protein (PTHrP), a mitogenic factor for renal cells, is overexpressed in acute renal failure (ARF). Recent data support an association between PTHrP and the renin-angiotensin system in the damaged kidney. The effects of angiotensin II (Ang II) inhibitors (quinapril, enalapril, and/or losartan) on PTHrP and the PTH1 receptor (PTH1R) expression in rats with either foli...

2018
Marcel Hanisch Lale Hanisch Johannes Kleinheinz Susanne Jung

BACKGROUND Primary failure of eruption (PFE) is a rare disease defined as incomplete tooth eruption despite the presence of a clear eruption pathway. Orthodontic extrusion is not feasible in this case because it results in ankylosis of teeth. To the best of our knowledge, besides the study of Ahmad et al. (Eur J Orthod 28:535-540, 2006), no study has systematically analysed the clinical feature...

2014
Benjamin H. Mullin Cyril Mamotte Richard L. Prince Scott G. Wilson

Osteoporosis is a common bone disease that has a strong genetic component. Genome-wide linkage studies have identified the chromosomal region 3p14-p22 as a quantitative trait locus for bone mineral density (BMD). We have previously identified associations between variation in two related genes located in 3p14-p22, ARHGEF3 and RHOA, and BMD in women. In this study we performed knockdown of these...

2015
Naoki Okubo Hiroyoshi Fujiwara Yoichi Minami Tatsuya Kunimoto Toshihiro Hosokawa Yasuhiro Umemura Hitoshi Inokawa Maki Asada Ryo Oda Toshikazu Kubo Kazuhiro Yagita

BACKGROUND AND PURPOSE The circadian clock governs endogenous day-night variations. In bone, the metabolism and growth show diurnal rhythms. The circadian clock is based on a transcription-translation feedback loop composed of clock genes including Period2 (Per2), which encodes the protein period circadian protein homolog 2. Because plasma parathyroid hormone (PTH) levels show diurnal variation...

Journal: :The Journal of biological chemistry 1999
D A Rubin P Hellman L I Zon C J Lobb C Bergwitz H Jüppner

Genomic and cDNA clones encoding portions of a putative catfish parathyroid hormone (PTH) 2 receptor (PTH2R) led to the isolation of a cDNA encoding a full-length zebrafish PTH2R (zPTH2R). The zPTH2R shared 63 and 60% amino acid sequence identity with human and rat PTH2Rs, respectively, 47-52% identity with mammalian and frog PTH/PTHrP receptors (PTH1R), and less than 37% with other members of ...

Journal: :American journal of physiology. Renal physiology 2003
Jianming Ba Dennis Brown Peter A Friedman

Inorganic phosphate (Pi) is absorbed by proximal tubules through a cellular pathway that is inhibited by parathyroid hormone (PTH). The calcium-sensing receptor (CaSR) is expressed on apical membranes of proximal tubules. In the present studies, we determined the effect of luminal and/or basolateral PTH on phosphate absorption and tested the hypothesis that CaSR activation blocks PTH-inhibitabl...

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