medicinal plants have been investigated for possible anti-cancer effects. the aim of the present study was to examine the cytotoxic activity of several medicinal plants on different tumor cell lines. 11 selected plant species which have been used in folkloric prescriptions were collected from different sites of hamedan district of iran. the methanolic extracts of the plants were prepared and th...

cancer is one of the main causes of mortality in the world which appears by the effect of enviromental physico-chemical mutagen and carcinogen agents. the identification of new cytotoxic drugs with low side effects on immune system has developed as important area in new studies of immunopharmacology. thymoquinone (tq), derived from the medicinal spice nigella sativa (also called black cumin) ex...

aim : in this paper effect of combinational usage of calprotectin and etoposide on ags cell line is studied. background : application of combined toxic agents such as etoposide and cicplatin are commonly used for chemotherapy purposes. as a matter of fact, calprotectin and etoposide were both applied on human gastric adenocarcinoma cell line (ags) as antitumor agents. both calprotectin and etop...

background: the extensive use of different nanoparticles has raised great concerns about their occupational and biological safety. objective: the aim of this study was to evaluate the cytotoxic effect of zinc oxide nanoparticles (zno nps) on viability of spermatozoa. materials and methods: semen samples were obtained from 15 healthy persons, and were analyzed using who guidelines. each semen sa...

objectives the current study aimed to investigate the immunostimulatory effects of the aqueous extract of heracleum persicum on mouse peritoneal macrophages. background the immune system provides protection against infectious diseases that are caused by various microorganisms, in particular pathogenic fungi. utilization of herbal immunostimulants is one solution to improve the immunity of human...

background: the anti-cancer effects of honey bee venom (bv) and chrysin might open a new window for treatment of chemo-resistant cancers. this study was designed to evaluate cytotoxic and pro-apoptotic effects of bv and chrysin on a2780cp cistplatin- resistant human ovarian cancer cells. methods: as per the study objectives, a2780cp cells were categorized to 4 groups: 3 experiment groups (treat...

Background: The anti-cancer effects of honey bee venom (BV) and chrysin might open a new window for treatment of chemo-resistant cancers. This study was designed to evaluate cytotoxic and pro-apoptotic effects of BV and chrysin on A2780cp cistplatin- resistant human ovarian cancer cells. Methods: As per the study objectives, A2780cp cells were categorized to 4 groups: 3 experiment groups (treat...

Multiple endocrine neoplasia type 1 (MEN1) is a syndrome characterized by tumors in multiple endocrine tissues such as the parathyroid glands, the pituitary gland, and the enteropancreatic neuroendocrine tissues. MEN1 is usually caused by mutations in the MEN1 gene that codes for the protein menin. Menin interacts with proteins that regulate transcription, DNA repair and processing, and mainten...

To study the regulatory effect of lncRNA HOTAIR/miR-20a-5p/HMGA2 axis on breast cancer (BC) cell growth, cell mobility, invasiveness, and apoptosis. The microarray data of lncRNAs and mRNAs with differential expression in BC tissues were analyzed in the Cancer Genome Atlas (TCGA) database. LncRNA HOX transcript antisense RNA (lncRNA HOTAIR) expression in BC was assessed by qRT-PCR. Cell viabili...